Structure
A-357300, Inhibitor
A-357300
Purity
>98% (HPLC)
Synonyms
A-357300; A357300; inhibitor
Purity/Purification
>98% (HPLC)
Target
Aminopeptidase
Receptor
Aminopeptidase
Chemical Name
N'-((2S, 3R)-3-amino-2-hydroxy-5-(isopropylthio)pentanoyl)-3-chlorobenzohydrazide
SMILES
O=C(NNC([C@@H](O)[C@H](N)CCSC(C)C)=O)C1=CC=CC(Cl)=C1
Molecular Formula
C15H22ClN3O3S
CAS Number
369358-07-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for A-357300, inhibitor
A-357300 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 0.12uM, does not inhibit MetAP1 or leucine aminopeptidases at 10uM; suppresses tumor growth preclinically without the toxicities observed with TNP-470, induces cytostasis by cell cycle arrest at the G (1) phase selectively in endothelial cells and in a subset of tumor cells, but not in most primary cells of nonendothelial type; inhibits angiogenesis both in vitro and in vivo and shows potent antitumor efficacy in carcinoma, sarcoma, and neuroblastoma murine models.
Product Categories/Family for A-357300, inhibitor
References
1. Wang J, et al. Cancer Res. 2003 Nov 15; 63 (22):7861-9.
2. Sheppard GS, et al. Bioorg Med Chem Lett. 2004 Feb 23; 14 (4):865-8.
3. Morowitz MJ, et al. Clin Cancer Res. 2005 Apr 1; 11 (7):2680-5.
2. Sheppard GS, et al. Bioorg Med Chem Lett. 2004 Feb 23; 14 (4):865-8.
3. Morowitz MJ, et al. Clin Cancer Res. 2005 Apr 1; 11 (7):2680-5.
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Product Notes
The A-357300 (Catalog #AAA3604269) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "A-357300, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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