Structure
SR 48692 Biochemical
SR 48692
Purity
>98% (HPLC)
Synonyms
SR 48692; Meclinertant; SR48692; SR-48692; SR 48692 biochemical
Purity/Purification
>98% (HPLC)
Target
Neurotensin Receptor
Receptor
Neurotensin Receptor
Chemical Name
(1r, 3r, 5r, 7r)-2-(1-(7-chloroquinolin-4-yl)-5-(2, 6-dimethoxyphenyl)-1H-pyrazole-3-carboxamido)adamantane-2-carboxylic acid
SMILES
O=C(NC1(C(O)=O)[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C4=NN(C5=CC=NC6=CC(Cl)=CC=C56)C(C7=C(OC)C=CC=C7OC)=C4
Molecular Formula
C32H31ClN4O5
CAS Number
146362-70-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SR 48692 biochemical
A potent, selective and orally active nonpeptide antagonist of the neurotensin receptor with IC50 of 0.99nM (guinea pig), without any intrinsic agonist activity; blocks K (+)-evoked release of [3H]dopamine stimulated by neurotensin in guinea pig striatal slices with IC50 of 0.46nM, competitively antagonizes neurotensin-induced intracellular Ca2+ mobilization with pA2 of 8.13 in H29 cells; reverses the turning behavior induced by intrastriatal injection of neurotensin in mice. Lung Cancer Phase 2 Clinical
Product Categories/Family for SR 48692 biochemical
References
1. Dubuc I, et al. Br J Pharmacol. 1994 Jun; 112 (2):352-4.
2. Steinberg R, et al. Neuroscience. 1994 Apr; 59 (4):921-9.
3. Brouard A, et al. Eur J Pharmacol. 1994 Mar 3; 253 (3):289-91.
4. Gully D, et al. Proc Natl Acad Sci U S A. 1993 Jan 1; 90 (1):65-9.
2. Steinberg R, et al. Neuroscience. 1994 Apr; 59 (4):921-9.
3. Brouard A, et al. Eur J Pharmacol. 1994 Mar 3; 253 (3):289-91.
4. Gully D, et al. Proc Natl Acad Sci U S A. 1993 Jan 1; 90 (1):65-9.
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Product Notes
The SR 48692 (Catalog #AAA3601989) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SR 48692, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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