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Siponimod Biochemical

Siponimod

Purity
>98% (HPLC)
Synonyms
Siponimod; BAF-312; Siponimod biochemical
Ordering
For Research Use Only!
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=30mg/mL
Target
Lysophospholipid Receptor
Receptor
S1P1; S1P2; S1P3; S1P4; S1P5
Chemical Name
3-Azetidinecarboxylic acid, 1-[[4-[(1E)-1-[[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino]ethyl]-2-ethylphenyl]methyl]
SMILES
CCC1=C(CN2CC(C(O)=O)C2)C=CC(/C(C)=N/OCC3=CC(C(F)(F)F)=C(C4CCCCC4)C=C3)=C1
Molecular Formula
C29H35F3N2O3
CAS Number
1230487-00-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Related Product Information for Siponimod biochemical
Siponimod (BAF312) is a potent, selective S1P1/S1P5 receptor modulator with EC50 of 0.39/0.0.98nM, >1,000-fold selectivity over S1P2/3/4; suppresses ongoing disease symptoms in rat EAE, concentration-dependently increases GIRK current amplitude in atrial myocytes with EC50 of 15.8nM, reduces peripheral absolute lymphocyte counts in vivo, exhibits potential as a treatment for immune-mediated diseases. Multiple Sclerosis Phase 3 Clinical
Product Categories/Family for Siponimod biochemical
References
1. Pan S, et al. ACS Med Chem Lett. 2013 Jan 4; 4 (3):333-7.
2. Gergely P, et al. Br J Pharmacol. 2012 Nov; 167 (5):1035-47.
3. Fryer RM, et al. PLoS One. 2012; 7 (12):e52985.
4. Selmaj K, et al. Lancet Neurol. 2013 Aug; 12 (8):756-67.

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Product Notes

The Siponimod (Catalog #AAA3600909) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Siponimod, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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