BMS-817399, Inhibitor

BMS-817399

• Purity: >98% (HPLC)
• Synonyms: BMS-817399; BMS817399; inhibitor

• Purity/Purification: >98% (HPLC)

• Target: Chemokine Receptor
• Receptor: Chemokine Receptor
• Chemical Name: 1-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3, 3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-3-(2-hydroxy-2-methylpropyl)urea
• SMILES: CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)(C)O
• Molecular Formula: C23H36ClN3O4
• CAS Number: 1202400-18-7
• Preparation and Storage: Store at -20 degree C; Stability: >=2 years; Shipping: Ice Pack

Structure

Related Product Information for BMS-817399, inhibitor

BMS-817399 is a potent, selective, orally bioavailable CCR1 antagonist with binding IC50 of 1nM, inhibits MIP-1alpha-induced chemotaxis with IC50 of 6nM; shows no binding activity to other CC family receptors, including CCR2, CCR3, CCR4, CCR5, CXCR2, CXCR3, and CXCR5, as well as a broad panel of other GPCRs and biogenic amine transporters; blocks MIP1alpha- and LKN-1-mediated up-regulation of CD11b in human whole blood with IC50 values of 25nM and 42nM, respectively; shows potential for the treatment of rheumatoid arthritis. Rheumatoid Arthritis Phase 2 Discontinued

Product Categories/Family for BMS-817399, inhibitor

Rheumatoid Arthritis; GPCR/G Protein; Inflammation/Immunology

References

1. Santella JB 3rd, et al. J Med Chem. 2014 Sep 25; 57 (18):7550-64.