Interleukin-2 (IL-2) Western Blot Control | IL-2 western blot control

Interleukin-2 (IL-2) (Western Blot Control)

Cat. Num. AAA343068

• Gene Names: IL2; IL-2; TCGF; lymphokine
• Purity: >= 95% (SDS PAGE)
• Synonyms: Interleukin-2 (IL-2); Interleukin-2 (IL-2) (Western Blot Control); IL-2; T-Cell Growth Factor; TCGF.; IL-2 western blot control

• Purity/Purification: >= 95% (SDS PAGE)
• Form/Format: Liquid
• Sequence Length: 153

• Buffer: Buffered 50% glycerol

Related Product Information for IL-2 western blot control

Interleukin-2 is a pleiotropic cytokine produced primarily by mitogenic or antigen activated T lymphocytes. IL-2 plays a key role in T cell proliferation and promotes the proliferation, expansion and differentiation of a wide variety of antigen specific cells. Recombinant Interleukin-2 comprises a 133 amino acid fragment (21-153) corresponding to the mature Interleukin-2 protein and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.

Product Categories/Family for IL-2 western blot control

Recombinant Proteins; Interleukin-2

References

Fletcher, M. & Goldstein, A.L. (1987) Lymphokine Res. 6(1): 45- 57. Jelinek, D.F. et al., (1986) Eur. J. Immunol. 16(8): 925- 932.

NCBI and Uniprot Product Information

• NCBI GI #: 512412
• NCBI GeneID: 3558
• UniProt Accession #: P60568; P01585
• Molecular Weight: 17,628 Da
• NCBI Official Full Name: interleukin-2
• NCBI Official Synonym Full Names: interleukin 2
• NCBI Official Symbol: IL2
• NCBI Official Synonym Symbols: IL-2; TCGF; lymphokine
• NCBI Protein Information: interleukin-2
• UniProt Protein Name: Interleukin-2
• Protein Family: Interleukin
• UniProt Gene Name: IL2
• UniProt Synonym Gene Names: IL-2; TCGF
• UniProt Entry Name: IL2_HUMAN

NCBI Description

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

Uniprot Description

IL2: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family.

Protein type: Oncoprotein; Secreted; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q26-q27

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; growth factor activity; interleukin-2 receptor binding; kinase activator activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: cell adhesion; cell-cell signaling; immune response; MAPKKK cascade; natural killer cell activation; negative regulation of apoptosis; negative regulation of B cell apoptosis; positive regulation of activated T cell proliferation; positive regulation of B cell proliferation; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of inflammatory response; positive regulation of interleukin-17 production; positive regulation of tissue remodeling; positive regulation of tyrosine phosphorylation of Stat5 protein; T cell differentiation