Mouse anti-Human CD106 Monoclonal Antibody | anti-CD106 antibody
Mouse Anti-Human CD106 Monoclonal Antibody, Azide Free Clone B-N8
Reactivity
Human
Applications
ELISA
Purity
Ion exchange chromatography
Synonyms
CD106; Monoclonal Antibody; Mouse Anti-Human CD106 Monoclonal Antibody; Azide Free Clone B-N8; VCAM-1; anti-CD106 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG1 Kappa light chain
Clone Number
B-N8
Specificity
Recognises the Vascular Cellular Adhesion Molecule-1 (VCAM-1), a 110 kDa protein
Purity/Purification
Ion exchange chromatography
Form/Format
Azide free
Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free
Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free
Applicable Applications for anti-CD106 antibody
ELISA (EIA)
Antigen
CD106 / VCAM-1
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Activated human umbilical vein endothelial cells
Preparation and Storage
1 year: 2-8°C
Long Term: (Aliquot) -20°C.
Long Term: (Aliquot) -20°C.
Related Product Information for anti-CD106 antibody
BACKGROUND:The vascular cell adhesion protein 1, also known as vascular cell adhesion molecule 1 (VCAM-1) or differentiation group 106 (CD106), is a protein that in humans is coded by the VCAM1 gene. VCAM-1 functions as a cell adhesion molecule.
The VCAM-1 protein induces the adhesion of lymphocytes, monocytes, eosinophils and basophils to the vascular endothelium. It also plays a role in signal transduction of leukocyte-endothelial cells and may play a role in the development of atherosclerosis and rheumatoid arthritis.
Positive regulation of VCAM-1 in endothelial cells by cytokines results from increased transcription of the gene (eg, in response to tumor necrosis factor alpha (TNF-?) and interleukin-1 (IL-1 )) and the stabilization of the messenger RNA. (MRNA) (e.g., interleukin-4 (IL-4)). The promoter region of the VCAM-1 gene contains functional tandem sites NF-KB (nuclear factor-kappa B). The sustained expression of VCAM-1 lasts more than 24 hours.
Mainly, the VCAM-1 protein is an endothelial ligand of the VLA-4 (Very Late Antigen-4 or ?4?1 integrin) of the ?1 integrin subfamily. VCAM-1 expression has also been observed in other cell types (eg, smooth muscle cells). It has also been shown to interact with EZR and Moesin.
CD106 also exists on the surface of certain sub-populations of mesenchymal stem cells (MSCs).
The VCAM-1 protein induces the adhesion of lymphocytes, monocytes, eosinophils and basophils to the vascular endothelium. It also plays a role in signal transduction of leukocyte-endothelial cells and may play a role in the development of atherosclerosis and rheumatoid arthritis.
Positive regulation of VCAM-1 in endothelial cells by cytokines results from increased transcription of the gene (eg, in response to tumor necrosis factor alpha (TNF-?) and interleukin-1 (IL-1 )) and the stabilization of the messenger RNA. (MRNA) (e.g., interleukin-4 (IL-4)). The promoter region of the VCAM-1 gene contains functional tandem sites NF-KB (nuclear factor-kappa B). The sustained expression of VCAM-1 lasts more than 24 hours.
Mainly, the VCAM-1 protein is an endothelial ligand of the VLA-4 (Very Late Antigen-4 or ?4?1 integrin) of the ?1 integrin subfamily. VCAM-1 expression has also been observed in other cell types (eg, smooth muscle cells). It has also been shown to interact with EZR and Moesin.
CD106 also exists on the surface of certain sub-populations of mesenchymal stem cells (MSCs).
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Product Notes
The CD106 (Catalog #AAA335069) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human CD106 Monoclonal Antibody, Azide Free Clone B-N8 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD106 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the CD106 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD106, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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