Western Blot (WB)
(Host: RabbitTarget Name: RSPO3Sample Tissue: Mouse Lung lysatesAntibody Dilution: 1ug/ml)
Rabbit anti-Mouse RSPO3 Polyclonal Antibody | anti-RSPO3 antibody
RSPO3 Antibody-middle region
Reactivity
Mouse
Applications
Western Blot
Purity
Affinity Purified
Synonyms
RSPO3; Polyclonal Antibody; RSPO3 Antibody-middle region; R-spondin-3; Thsd2; AW742308; Cristin1; 2810459H04Rik; anti-RSPO3 antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration
Batch dependent within range: 100ul at 0.5-1mg/ml (varies by lot)
Sequence
TSETRTCIVQRKKCSKGERGKKGRERKRKKLNKEERKETSSSSDSKGLES
Applicable Applications for anti-RSPO3 antibody
Western Blot (WB)
Protein Size
277 amino acids
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of mouse RSPO3
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Western Blot (WB)
(Host: RabbitTarget Name: RSPO3Sample Tissue: Mouse Lung lysatesAntibody Dilution: 1ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: RSPO3Sample Tissue: Mouse Lung lysatesAntibody Dilution: 1ug/ml)
Related Product Information for anti-RSPO3 antibody
Description of Target: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells.
NCBI and Uniprot Product Information
NCBI GeneID
UniProt Accession #
Molecular Weight
30kDa
UniProt Protein Name
R-spondin-3
Protein Family
UniProt Gene Name
Rspo3
UniProt Synonym Gene Names
Cristin-1
UniProt Entry Name
RSPO3_MOUSE
Uniprot Description
R-spondin-3: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Belongs to the R-spondin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Cell development/differentiation; Secreted, signal peptide
Cellular Component: extracellular region
Molecular Function: frizzled binding; heparin binding; receptor binding
Biological Process: angiogenesis; blood vessel remodeling; sprouting angiogenesis
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Product Notes
The RSPO3 rspo3 (Catalog #AAA3249862) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RSPO3 Antibody-middle region reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's RSPO3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the RSPO3 rspo3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: TSETRTCIVQ RKKCSKGERG KKGRERKRKK LNKEERKETS SSSDSKGLES. It is sometimes possible for the material contained within the vial of "RSPO3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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