TCHP blocking peptide
TCHP Peptide - C-terminal region
Gene Names
TCHP; TpMs
Reactivity
Human
Applications
Western Blot
Synonyms
TCHP; TCHP Peptide - C-terminal region; TCHP blocking peptide
Reactivity
Human
Form/Format
Lyophilized powder
Sequence
IQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE
Sequence Length
498
Applicable Applications for TCHP blocking peptide
Western Blot (WB)
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Related Product Information for TCHP blocking peptide
This is a synthetic peptide designed for use in combination with anti-TCHP Antibody, made
Target Description: TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.
Target Description: TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.
Product Categories/Family for TCHP blocking peptide
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
61kDa
NCBI Official Full Name
trichoplein keratin filament-binding protein
NCBI Official Synonym Full Names
trichoplein keratin filament binding
NCBI Official Symbol
TCHP
NCBI Official Synonym Symbols
TpMs
NCBI Protein Information
trichoplein keratin filament-binding protein
UniProt Protein Name
Trichoplein keratin filament-binding protein
Protein Family
UniProt Gene Name
TCHP
UniProt Synonym Gene Names
Protein TCHP; Mitostatin
UniProt Entry Name
TCHP_HUMAN
Uniprot Description
TCHP: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Belongs to the TCHP family.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: centrosome; apical cortex; mitochondrion; keratin filament; cytoplasm; plasma membrane
Molecular Function: protein binding
Biological Process: apoptosis; negative regulation of cell growth
Research Articles on TCHP
Similar Products
Product Notes
The TCHP tchp (Catalog #AAA3239760) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The TCHP Peptide - C-terminal region reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TCHP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the TCHP tchp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: IQEKIEQNRR AQEESLKHRE QLIRNLEEVR ELARREKEES EKLKSARKQE. It is sometimes possible for the material contained within the vial of "TCHP, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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