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Western Blot (WB) (Western Blot analysis of MEIS2 on different lysates using anti-MEIS2 antibody at 1/500 dilution. Positive control:Lane 1: Mouse testis Lane 2: SH-SY-5YLane 3: Mouse lung)

Rabbit anti-Human, Mouse MEIS2 Polyclonal Antibody | anti-MEIS2 antibody

MEIS2 Polyclonal Antibody

Reactivity
Human, Mouse
Applications
Western Blot, Flow Cytometry, Functional Assay
Purity
ProA affinity purified
Synonyms
MEIS2; Polyclonal Antibody; MEIS2 Polyclonal Antibody; MRG1; Homeobox protein Meis2; HsT18361; Meis (mouse) homolog 2; Meis homeobox 2; Meis homolog 2; Meis1 myeloid ecotropic viral integration site 1 homolog 2 (mouse); Meis1 myeloid ecotropic viral integration site 1 homolog 2; Meis1 related gene 1; Meis1 related protein 1; Meis1-related protein 1; MGC2820; TALE homeobox protein Meis2; anti-MEIS2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
MEIS2 polyclonal antibody detects endogenous levels of MEIS2 protein.
Purity/Purification
ProA affinity purified
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
381
Applicable Applications for anti-MEIS2 antibody
Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes
WB: 1:500-1:1,000
FC/FACS: 1:50-1:100
Immunogen
Recombinant protein
Preparation and Storage
Store at 4 degree C after thawing.
Aliquot store at -20 degree C or -80 degree C.
Avoid repeated freeze/thaw cycles.

Western Blot (WB)

(Western Blot analysis of MEIS2 on different lysates using anti-MEIS2 antibody at 1/500 dilution. Positive control:Lane 1: Mouse testis Lane 2: SH-SY-5YLane 3: Mouse lung)

Western Blot (WB) (Western Blot analysis of MEIS2 on different lysates using anti-MEIS2 antibody at 1/500 dilution. Positive control:Lane 1: Mouse testis Lane 2: SH-SY-5YLane 3: Mouse lung)

Flow Cytometry (FC/FACS)

(Flow cytometric analysis of K562 cells with MEIS2 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.)

Flow Cytometry (FC/FACS) (Flow cytometric analysis of K562 cells with MEIS2 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.)
Related Product Information for anti-MEIS2 antibody
Profilins regulate Actin polymerization by binding to and sequestering the Actin monomer. Profilins act as a nucleotide exchange factor that charges Actin with ATP after binding the Actin monomer through a 1: 1 stoichiometric relationship. Human Profilin-1 and Profilin-2 are encoded by two separate genes mapping to chromosomes 17p13.2 and 3q25.1, respectively. Both Profilin-1 and Profilin-2 are abundantly expressed in kidney. Profilin-1 is highly expressed in lung, liver, placenta and kidney while Profilin-2 is highly expressed in brain and skeletal muscle. In axonal and dendritic processes of mouse brain, Profilins co-localize with dynamin I and synapsin. Profilin may play a role in mediating cell adhesion. The overexpression of Profilin in endothelial cells results in increased adhesion to Fibronectin. In food allergy, plant Profilin is considered a pan-allergen. Case studies indicate individuals with allergies to various foods including celery, carrots, zucchini and peanuts are actually sensitive to the Profilin proteins in these foods.

NCBI and Uniprot Product Information

NCBI GI #
UniProt Accession #
Molecular Weight
51kDa
NCBI Official Full Name
Meis homeobox 2
UniProt Protein Name
Homeobox protein Meis2
Protein Family
UniProt Gene Name
MEIS2
UniProt Synonym Gene Names
MRG1
UniProt Entry Name
MEIS2_HUMAN

Uniprot Description

MEIS2: a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: nucleus

Molecular Function: protein binding; sequence-specific DNA binding; transcription cofactor activity; transcription factor activity; transcription factor binding; transcription corepressor activity

Biological Process: transcription from RNA polymerase II promoter; negative regulation of myeloid cell differentiation; eye development; response to mechanical stimulus; pancreas development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter

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Product Notes

The MEIS2 meis2 (Catalog #AAA3013021) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MEIS2 Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's MEIS2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Flow Cytometry (FC/FACS). WB: 1:500-1:1,000 FC/FACS: 1:50-1:100. Researchers should empirically determine the suitability of the MEIS2 meis2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MEIS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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