Rabbit DNAI1 Polyclonal Antibody | anti-DNAI1 antibody

DNAI1 Polyclonal Antibody

Cat. Num. AAA3012603

• Gene Names: DNAI1; PCD; DIC1; ICS1; CILD1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: ProA affinity purified
• Synonyms: DNAI1; Polyclonal Antibody; DNAI1 Polyclonal Antibody; Axonemal dynein intermediate chain 1; Axonemal dynein intermediate chain 2; CILD 1; CILD1; Cytoplasmic dynein 1 intermediate chain 1; Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 1; Cytoplasmic dynein intermediate chain 2; DH IC 1; DH IC 2; DIC1; DNAI 1; DNAI 2; DNAI2; DNCI 2; DNCI1; DNCI2; DNCIC 1; DNCIC 2; DNCIC1; DNCIC2; DYNC1I1; DYNC1I2; Dynein axonemal intermediate chain 1; Dynein axonemal intermediate polypeptide 1; Dynein axonemal intermediate polypeptide 2; Dynein cytoplasmic intermediate polypeptide 1; Dynein cytoplasmic intermediate polypeptide 2; Dynein intermediate chain 1 axonemal; Dynein intermediate chain 1 cytosolic; Dynein intermediate chain 1; axonemal; Dynein intermediate chain 2 axonemal; Dynein intermediate chain 2 cytosolic; Dynein intermediate chain DNAI1; IC74; ICS; ICS1; Immotile cilia syndrome 1; MGC26204; PCD; anti-DNAI1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: DNAI1 polyclonal antibody detects endogenous levels of DNAI1 protein.
• Purity/Purification: ProA affinity purified
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 699

• Applicable Applications for anti-DNAI1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:1,000; IHC: 1:50-1:200
• Immunogen: Recombinant protein
• Preparation and Storage: Store at 4 degree C after thawing.; Aliquot store at -20 degree C or -80 degree C.; Avoid repeated freeze/thaw cycles.

Immunohistochemsitry (IHC)

(Fig1:Immunohistochemical analysis of paraffin-embedded mouse fallopian tube tissue using anti-Dynein intermediate chain 1 antibody. Counter stained with hematoxylin.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded mouse testes tissue using anti-Dynein intermediate chain 1 antibody. Counter stained with hematoxylin.)

Related Product Information for anti-DNAI1 antibody

Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; the complex transports cellular cargos towards the central region of the cell. Axonemal Dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. Cytoplasmic Dyneins, such as Dynein IC1, cytosolic and Dynein IC2, cytosolic, comprise an approximately 12 subunit complex of two heavy chains, two intermediate chains to anchor Dynein to its cargo, four smaller intermediate chains and several light chains. This complex performs functions necessary for cell survival, such as organelle transport and centrosome assembly. The carboxy terminus of Dynein is important for microtubule-dependent motility and is highly conserved, while the amino terminal regions are more variable. Several proteins regulate Dynein activity, including dynactin, LIS1 and NudEL(NudE-like).

NCBI and Uniprot Product Information

• NCBI GI #: 12643888
• NCBI GeneID: 27019
• UniProt Accession #: Q9UI46; Q8C0M8; Q5XIL8
• Molecular Weight: 79kDa
• NCBI Official Full Name: Dynein intermediate chain 1, axonemal
• NCBI Official Synonym Full Names: dynein axonemal intermediate chain 1
• NCBI Official Symbol: DNAI1
• NCBI Official Synonym Symbols: PCD; DIC1; ICS1; CILD1
• NCBI Protein Information: dynein intermediate chain 1, axonemal
• UniProt Protein Name: Dynein intermediate chain 1, axonemal
• Protein Family: Dynein
• UniProt Gene Name: DNAI1
• UniProt Entry Name: DNAI1_HUMAN

NCBI Description

This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]