Rabbit anti-Human, Mouse MLN Polyclonal Antibody | anti-MLN antibody

MLN Polyclonal Antibody

Cat. Num. AAA3011538

• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: MLN; Polyclonal Antibody; MLN Polyclonal Antibody; Promotilin; anti-MLN antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: MLN polyclonal antibody detects endogenous levels of MLN protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 115

• Applicable Applications for anti-MLN antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200
• Immunogen: Recombinant full length Human MLN.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human stomach using MLN antibody at dilution of 1:100 (40x lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse brain using MLN antibody at dilution of 1:100 (40x lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse heart using MLN antibody at dilution of 1:100 (40x lens).)

Related Product Information for anti-MLN antibody

Motilin, also known as MLN, is a 115 amino acid secreted peptide that is a cleavage product of the promotilin precursor, a protein that is proteolytically processed to yield motilin and motilin-associated peptide (MAP). Existing in the cells of the small intestine, motilin plays an important role in the rhythmic contraction of duodenal and colonic smooth muscle and is also involved in the regulation of interdigestive gastrointestinal motility. The gene encoding motilin maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.

NCBI and Uniprot Product Information

• NCBI GI #: 386955
• UniProt Accession #: P12872
• Molecular Weight: ~ 13kDa
• NCBI Official Full Name: motilin
• UniProt Protein Name: Promotilin
• Protein Family: Motilin
• UniProt Gene Name: MLN
• UniProt Synonym Gene Names: MAP
• UniProt Entry Name: MOTI_HUMAN

Uniprot Description

MLN: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle. Belongs to the motilin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: extracellular region

Molecular Function: hormone activity; receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling