Rabbit CPLX2 Polyclonal Antibody | anti-CPLX2 antibody

CPLX2 Polyclonal Antibody

Cat. Num. AAA3008868

• Gene Names: CPLX2; CPX2; Hfb1; 921-L; CPX-2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: CPLX2; Polyclonal Antibody; CPLX2 Polyclonal Antibody; CPX2; Hfb1; 921-L; CPX-2; anti-CPLX2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CPLX2 polyclonal antibody detects endogenous levels of CPLX2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 134

• Applicable Applications for anti-CPLX2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant protein of human CPLX2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using CPLX2 antibody.)

Related Product Information for anti-CPLX2 antibody

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 51316998
• NCBI GeneID: 10814
• UniProt Accession #: Q6PUV4
• Molecular Weight: ~ 15kDa
• NCBI Official Full Name: Complexin-2
• NCBI Official Synonym Full Names: complexin 2
• NCBI Official Symbol: CPLX2
• NCBI Official Synonym Symbols: CPX2; Hfb1; 921-L; CPX-2
• NCBI Protein Information: complexin-2
• UniProt Protein Name: Complexin-2
• Protein Family: Complexin
• UniProt Gene Name: CPLX2
• UniProt Synonym Gene Names: CPX II
• UniProt Entry Name: CPLX2_HUMAN

NCBI Description

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CPLX2: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis. Belongs to the complexin/synaphin family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 5q35.2

Cellular Component: mast cell granule; cell soma; dendrite; synapse; cytosol

Molecular Function: syntaxin-1 binding; calcium-dependent protein binding

Biological Process: regulation of exocytosis; nervous system development; synaptic vesicle exocytosis; positive regulation of synaptic plasticity; mast cell degranulation; cell differentiation; vesicle docking during exocytosis