Rabbit IL20RA Polyclonal Antibody | anti-IL20RA antibody

IL20RA Polyclonal Antibody

Cat. Num. AAA3006979

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: IL20RA; Polyclonal Antibody; IL20RA Polyclonal Antibody; Interleukin-20 receptor subunit alpha; IL-20 receptor subunit alpha; IL-20R-alpha; IL-20RA; Cytokine receptor class-II member 8; Cytokine receptor family 2 member 8; CRF2-8; IL-20R1; ZcytoR7; UNQ681; PRO1315; anti-IL20RA antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: IL20RA polyclonal antibody detects endogenous levels of IL20RA protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 553

• Applicable Applications for anti-IL20RA antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human IL20RA
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of IL20RA polyclonal antibody at 1:500 dilutionLane1:MCF-7 whole cell lysateLane2:sp2/0 whole cell lysate Lane3:PC12 whole cell lysate)

Related Product Information for anti-IL20RA antibody

The class II cytokine receptor family includes 12 members, 11 of which combine as various heterodimers to transduce signals across the cellular membrane for 27 cytokines. These cytokines are divided into four structurally related groups: six cytokines of the IL-10 family, 17 type I IFNs, one type II IFN and three IFN-lambda. IL-20 is a member of the IL-10 family of cytokines that has been shown to be upregulated in psoriatic skin. The receptor for IL-20 (IL-20R) exists as a dimer consisting of IL-20Ralpha and IL-20Rbeta. IL-20R also functions as a receptor for IL-19, IL-24 and IL-26. It is highly expressed in skin, brain and testis. IL-20, IL-20Ralpha and IL-20Rbeta all have higher expression levels in psoriatic lesional (LS) skin than in nonlesional (NL) skin, suggesting a role for these proteins as potential therapeutic targets. IL-20 can induce signal transducer and activator of transcription (Stat) activation through IL-20R.

NCBI and Uniprot Product Information

• NCBI GI #: 31083156
• NCBI Accession #: NP_055247.2
• NCBI GenBank Nucleotide #: NP_055247.2
• UniProt Accession #: Q9UHF4
• Molecular Weight: ~ 62kDa
• NCBI Official Full Name: interleukin-20 receptor subunit alpha
• UniProt Protein Name: Interleukin-20 receptor subunit alpha
• Protein Family: Interleukin-20 receptor
• UniProt Gene Name: IL20RA
• UniProt Synonym Gene Names: IL-20 receptor subunit alpha; IL-20R-alpha; IL-20RA; CRF2-8
• UniProt Entry Name: I20RA_HUMAN

Uniprot Description

IL20RA: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26. Belongs to the type II cytokine receptor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-20 binding

Biological Process: regulation of bone resorption; cytokine and chemokine mediated signaling pathway