Rabbit anti-Human IL20RA Monoclonal Antibody | anti-IL20RA antibody

Recombinant Anti-IL20RA Antibody, Rabbit Monoclonal

Cat. Num. AAA8102645

• Gene Names: IL20RA; CRF2-8; IL-20R1; IL-20RA; IL-20R-alpha
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Protein A
• Synonyms: IL20RA; Monoclonal Antibody; Recombinant Anti-IL20RA Antibody; Rabbit Monoclonal; IL20RA/IL-20RA Antibody; Rabbit MAb; interleukin 20 receptor; alpha; Anti-CRF2-8 Antibody; Anti-IL-20R-alpha Antibody; Anti-IL-20R1 Antibody; Anti-IL-20RA Antibody; anti-IL20RA antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 038
• Specificity: Human IL20RA/IL-20RA.; No cross-reactivity in ELISA with Human IFNgR1, Human IL10RB
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-IL20RA antibody: ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: ELISA: 1:1000-1:2000; IHC-P: 1:100-1:500
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant Human IL20RA/IL-20RA protein
• Conjugation: Unconjugated
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human IL20RA/IL-20RA (rh IL20RA/IL-20RA).
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human IL20Ra in human skin with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to stratified squamous epithelium.)

Related Product Information for anti-IL20RA antibody

Interleukin 20 receptor, alpha subunit (IL20RA/IL-20RA) also known as IL-20 receptor subunit alpha, Cytokine receptor class-II member 8, interleukin-20 receptor I, and interleukin-20 receptor subunit alpha, is a subunit for the interleukin-20 receptor. IL20RA/IL-20RA belongs to the type II cytokine receptor family. This cytokine is a receptor for interleukin 20 (IL20), a cytokine that may be involved in the epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). IL20RA forms heterodimer with IL20RB and the complex serves as a receptor for IL19, IL20, and IL24. All three are capable of signaling through the IL-20RA/IL-20RB complex. The ligand binding to receptor B creating a high-affinity binding site for receptor A which is recruited to complete the complex. Besides, IL20RA also forms a heterodimer with the unique and specific receptor IL10RB and functions as the receptor for IL26. IL20RA is widely expressed with the highest levels in skin, testis, and brain. The expression of both IL20RA and IL20RB is found to be upregulated in psoriatic skin lesions on keratinocytes.

References

Parrish-Novak J, et al. (2002) Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem. 277(49): 47517-23.Kingo K, et al. (2008) Association analysis of IL20RA and IL20RB genes in psoriasis. Genes Immun. 9(5): 445-51.Blumberg H, et al. (2001) Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell. 104(1): 9-19.

NCBI and Uniprot Product Information

• NCBI GI #: 524590113
• NCBI GeneID: 53832
• NCBI Accession #: NP_055247.3
• NCBI GenBank Nucleotide #: NM_014432.3
• UniProt Accession #: Q9UHF4; Q14CW2; Q6UWA9; Q96SH8
• Molecular Weight: 62,485 Da
• NCBI Official Full Name: interleukin-20 receptor subunit alpha isoform 1
• NCBI Official Synonym Full Names: interleukin 20 receptor, alpha
• NCBI Official Symbol: IL20RA
• NCBI Official Synonym Symbols: CRF2-8; IL-20R1; IL-20RA; IL-20R-alpha
• NCBI Protein Information: interleukin-20 receptor subunit alpha; interleukin-20 receptor I; class II cytokine receptor ZCYTOR7; cytokine receptor family 2 member 8
• UniProt Protein Name: Interleukin-20 receptor subunit alpha
• Protein Family: Interleukin-20 receptor
• UniProt Gene Name: IL20RA
• UniProt Synonym Gene Names: IL-20 receptor subunit alpha; IL-20R-alpha; IL-20RA; CRF2-8
• UniProt Entry Name: I20RA_HUMAN

NCBI Description

This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

IL20RA: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26. Belongs to the type II cytokine receptor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-20 binding

Biological Process: regulation of bone resorption; cytokine and chemokine mediated signaling pathway