Rabbit CIB4 Polyclonal Antibody | anti-CIB4 antibody

CIB4 Polyclonal Antibody

Cat. Num. AAA3006397

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: CIB4; Polyclonal Antibody; CIB4 Polyclonal Antibody; Calcium and integrin-binding family member 4; anti-CIB4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CIB4 polyclonal antibody detects endogenous levels of CIB4 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 185

• Applicable Applications for anti-CIB4 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human CIB4.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of CIB4 polyclonal antibody at 1:500 dilutionLane1:HepG2 whole cell lysateLane2:Mouse kidney tissue lysateLane3:Rat liver tissue lysate)

Related Product Information for anti-CIB4 antibody

CIB4 (calciumand integrin-binding familymember 4) is a 185 amino acid protein thatcontainsthree EF-hand domains. CIB4 is closelyrelated to CIB (CIB has one less EF-hand domain), which isknown to bind to IntegrinalphaIIbeta in platelets and isinvolved in signal transduction. The gene encoding CIB4mapsto human chromosome 2, which houses over 1, 400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare andmorbid skin deformity, is associatedwithmutationsin the ABCA12 gene, while the lipidmetabolic disordersitosterolemia is associated with defectsin the ABCG5 and ABCG8 genes. Additionally, an extremelyrare recessive genetic disorder, Alströmsyndrome, iscaused bymutationsin the ALMS1 gene, whichmaps to chromosome 2.

NCBI and Uniprot Product Information

• NCBI GI #: 71274156
• NCBI Accession #: NP_001025052.1
• NCBI GenBank Nucleotide #: NP_001025052.1
• UniProt Accession #: A0PJX0
• Molecular Weight: ~ 22kDa
• NCBI Official Full Name: calcium and integrin-binding family member 4
• UniProt Protein Name: Calcium and integrin-binding family member 4
• Protein Family: Calcium and integrin-binding family
• UniProt Gene Name: CIB4
• UniProt Entry Name: CIB4_HUMAN

Uniprot Description

CIB4: Interacts with ITGA2B (via C-terminus cytoplasmic tail region); the interaction is stabilized/increased in a calcium- and magnesium-dependent manner

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 2p23.3

Molecular Function: calcium ion binding