Rabbit MT-ATP8 Polyclonal Antibody | anti-MT-ATP8 antibody

MT-ATP8 Polyclonal Antibody

Cat. Num. AAA3006384

• Gene Names: MT-ATP8; ATPase8; MTATP8; ATP8
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: MT-ATP8; Polyclonal Antibody; MT-ATP8 Polyclonal Antibody; ATP synthase protein 8; A6L; F-ATPase subunit 8; ATP8; ATPASE8; MTATP8; anti-MT-ATP8 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: MT-ATP8 polyclonal antibody detects endogenous levels of MT-ATP8 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 68

• Applicable Applications for anti-MT-ATP8 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human MT-ATP8.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of MT-ATP8 polyclonal antibody at 1:500 dilutionLane1:HepG2 whole cell lysateLane2:Mouse brain tissue lysateLane3:Rat stomach tissue lysate)

Related Product Information for anti-MT-ATP8 antibody

Mitochondrial ATP synthase is composed of two multi-subunit complexes that utilize an inner membrane electrochemical gradient to catalyze the synthesis of ATP during oxidative phosphorylation. The two multi-subunit complexes are designated F1 and F0, the former of which comprises the soluble catalytic core and the latter of which comprises the membrane-spanning proton channel of ATP synthase. ATP8, also known as MT-ATP8, ATPASE8 or MTATP8, is a 68 amino acid single-pass membrane protein that localizes to mitochondria and functions as a minor subunit of the F0 complex. The gene encoding ATP8 maps to the mitochondrial chromosome and may be involved in the pathogenesis of multiple sclerosis.

NCBI and Uniprot Product Information

• NCBI GI #: 251831111
• NCBI GeneID: 4509
• NCBI Accession #: YP_003024030.1
• NCBI GenBank Nucleotide #: YP_003024030.1
• UniProt Accession #: P03928
• Molecular Weight: ~ 8kDa
• NCBI Official Full Name: ATP synthase F0 subunit 8 (mitochondrion)
• NCBI Official Synonym Full Names: mitochondrially encoded ATP synthase 8
• NCBI Official Symbol: MT-ATP8
• NCBI Official Synonym Symbols: ATPase8; MTATP8; ATP8
• NCBI Protein Information: ATP synthase F0 subunit 8
• UniProt Protein Name: ATP synthase protein 8
• UniProt Gene Name: MT-ATP8
• UniProt Synonym Gene Names: ATP8; ATPASE8; MTATP8
• UniProt Entry Name: ATP8_HUMAN

Uniprot Description

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane ().