Immunohistochemistry (IHC)
(Immunohistochemistry (IHC) analyzes of BMP-3 (E306) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.)
Rabbit BMP3 Polyclonal Antibody | anti-BMP3 antibody
BMP3 (E306) Polyclonal Antibody
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
BMP3; Polyclonal Antibody; BMP3 (E306) Polyclonal Antibody; Bone morphogenetic protein 3; BMP-3; Bone morphogenetic protein 3A; BMP-3A; Osteogenin; BMP3A; anti-BMP3 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
BMP-3 (E306) polyclonal antibody detects endogenous levels of BMP-3 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
472
Applicable Applications for anti-BMP3 antibody
Immunohistochemistry (IHC)
Application Notes
IHC: 1:50-1:200
Immunogen
Synthetic peptide, corresponding to amino acids 261-310 of Human BMP-3.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunohistochemistry (IHC) analyzes of BMP-3 (E306) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.)
Immunohistochemistry (IHC)
(Immunohistochemistry (IHC) analyzes of BMP-3 (E306) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.)
Related Product Information for anti-BMP3 antibody
Bone morphogenic proteins (BMPs) are members of the TGFbeta superfamily. BMPs are involved in the induction of cartilage and bone formation. In vivo studies have shown that BMP-2 (also designated BMP-2A) and BMP-3 can independently induce cartilage formation. Smad3 association with the TGFbeta receptor complex and Smad1 translocation to the nucleus are observed after the addition of BMP-4 (also designated BMP-2B), suggesting that BMP-4 may play a role in activation of the Smad pathway. BMP-5, BMP-6 and BMP-7 all share high sequence homology with BMP-2, indicating that they each may be able to induce cartilage formation. BMP-8 (also designated OP-2) is thought to be involved in early development, as detectable expression has not been found in adult organs.
NCBI and Uniprot Product Information
NCBI GI #
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 54kDa
NCBI Official Full Name
bone morphogenetic protein 3 preproprotein
UniProt Protein Name
Bone morphogenetic protein 3
Protein Family
UniProt Gene Name
BMP3
UniProt Synonym Gene Names
BMP3A; BMP-3; BMP-3A
UniProt Entry Name
BMP3_HUMAN
Uniprot Description
BMP3: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. Belongs to the TGF-beta family.
Protein type: Secreted, signal peptide; Secreted; Cytokine
Chromosomal Location of Human Ortholog: 4q21
Cellular Component: extracellular space
Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding; receptor binding
Biological Process: regulation of apoptosis; ossification; cell-cell signaling; regulation of MAPKKK cascade; cartilage development; positive regulation of transcription from RNA polymerase II promoter; skeletal development; cell development; growth
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Product Notes
The BMP3 bmp3 (Catalog #AAA3004138) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BMP3 (E306) Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's BMP3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1:50-1:200. Researchers should empirically determine the suitability of the BMP3 bmp3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BMP3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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