Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Heart Tissue; Lane2: Mouse Liver Tissue; Lane3: Mouse Pancreas Tissue; Lane4: Mouse Stomach Tissue.)
Rabbit anti-Mouse Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 Polyclonal Antibody | anti-AIMP1 antibody
Polyclonal Antibody to Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- ATNDAVLKR LEQKGAEADQ IIEYLKQQVA LLKEKAILQA TMREEKKLRV ENAKLKKEIE ELKQELILAE IHNGVEQVRV RLSTPLQTNC TASESVVQSP SVATTASPAT KEQIKAGEEK KVKEKTEKKG EKKEKQQSAA ASTDSKPIDA SRLDLRIGCI VTAKKHPDAD SLYVEEVDVG EAAPRTVVSG LVNHVPLEQM QNRMVVLLCN LKPAKMRGVL SQAMVMCASS PEKVEILAPP NGSVPGDRIT FDAFPGEPDK
Immunocytochemistry in formalin fixed cells: 5-20ug/mL
Immunohistochemistry in formalin fixed frozen section: 5-20ug/mL
Immunohistochemistry in paraffin section: 5-20ug/mL
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Heart Tissue; Lane2: Mouse Liver Tissue; Lane3: Mouse Pancreas Tissue; Lane4: Mouse Stomach Tissue.)
Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Heart Tissue; Lane2: Mouse Liver Tissue; Lane3: Mouse Pancreas Tissue; Lane4: Mouse Stomach Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant AIMP1, Mouse.)
Western Blot (WB)
(Western Blot: Sample: Recombinant AIMP1, Mouse.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Kidney Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Kidney Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Uterus Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Uterus Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Liver Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Liver Tissue.)
NCBI and Uniprot Product Information
Uniprot Description
SCYE1: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1- mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. Defects in AIMP1 are the cause of leukodystrophy hypomyelinating type 3 (HLD3). A severe autosomal recessive hypomyelinating leukodystrophy characterized by early infantile onset of global developmental delay, lack of development, lack of speech acquisition, and peripheral spasticity associated with decreased myelination in the central nervous system. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Translation; Translation regulation
Chromosomal Location of Human Ortholog: 3|3 G3
Cellular Component: aminoacyl-tRNA synthetase multienzyme complex; cell surface; cytoplasm; cytoplasmic vesicle; cytosol; endoplasmic reticulum; extracellular region; extracellular space; Golgi apparatus; membrane; nucleus
Molecular Function: cytokine activity; GTPase binding; protein homodimerization activity; RNA binding; tRNA binding
Biological Process: angiogenesis; apoptosis; carbohydrate metabolic process; cell adhesion; cell-cell signaling; glucose metabolic process; inflammatory response; leukocyte migration; negative regulation of endothelial cell proliferation; translation; tRNA aminoacylation for protein translation
Research Articles on AIMP1
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Product Notes
The AIMP1 aimp1 (Catalog #AAA2028408) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-2ug/mL Immunocytochemistry in formalin fixed cells: 5-20ug/mL Immunohistochemistry in formalin fixed frozen section: 5-20ug/mL Immunohistochemistry in paraffin section: 5-20ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the AIMP1 aimp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- ATNDAVLKR LEQKGAEADQ IIEYLKQQVA LLKEKAILQA TMREEKKLRV ENAKLKKEIE ELKQELILAE IHNGVEQVRV RLSTPLQTNC TASESVVQSP SVATTASPAT KEQIKAGEEK KVKEKTEKKG EKKEKQQSAA ASTDSKPIDA SRLDLRIGCI VTAKKHPDAD SLYVEEVDVG EAAPRTVVSG LVNHVPLEQM QNRMVVLLCN LKPAKMRGVL SQAMVMCASS PEKVEILAPP NGSVPGDRIT FDAFPGEPDK. It is sometimes possible for the material contained within the vial of "Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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