Rabbit Na+ CP type IIalpha Polyclonal Antibody | anti-K1032 antibody

Na+ CP type IIalpha (K1032) Polyclonal Antibody

Cat. Num. AAA3003938

• Gene Names: SCN2A; HBA; NAC2; BFIC3; BFIS3; BFNIS; HBSCI; EIEE11; HBSCII; Nav1.2; SCN2A1; SCN2A2; Na(v)1.2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Na+ CP type IIalpha; Polyclonal Antibody; Na+ CP type IIalpha (K1032) Polyclonal Antibody; Sodium channel protein type 2 subunit alpha; HBSC II; Sodium channel protein brain II subunit alpha; Sodium channel protein type II subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.2; SCN2A; NAC2; SCN2A1; SCN2A2; anti-K1032 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Na+ CP type IIalpha (K1032) polyclonal antibody detects endogenous levels of Na+ CP type IIalpha protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 2005

• Applicable Applications for anti-K1032 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:1000; IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 1002-1052 of Human Na+ CP type IIalpha.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of Na+ CP type IIalpha (K1032) pAb at 1:1000 dilutionLane1:HEK293T whole cell lysate (40ug) Lane2:A549 whole cell lysate (40ug) Lane3:C6 whole cell lysate (40ug) Lane4:CT26 whole cell lysate (40ug))

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of Na+ CP type IIalpha (K1032) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.)

Related Product Information for anti-K1032 antibody

Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIalpha subunits are more abundant along axons. The beta1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.

NCBI and Uniprot Product Information

• NCBI GI #: 93141212
• NCBI GeneID: 6326
• NCBI Accession #: NP_001035232.1
• NCBI GenBank Nucleotide #: NP_001035232.1
• UniProt Accession #: Q99250
• Molecular Weight: ~ 230-260kDa
• NCBI Official Full Name: sodium channel protein type 2 subunit alpha isoform 1
• NCBI Official Synonym Full Names: sodium voltage-gated channel alpha subunit 2
• NCBI Official Symbol: SCN2A
• NCBI Official Synonym Symbols: HBA; NAC2; BFIC3; BFIS3; BFNIS; HBSCI; EIEE11; HBSCII; Nav1.2; SCN2A1; SCN2A2; Na(v)1.2
• NCBI Protein Information: sodium channel protein type 2 subunit alpha
• UniProt Protein Name: Sodium channel protein type 2 subunit alpha
• UniProt Gene Name: SCN2A
• UniProt Synonym Gene Names: NAC2; SCN2A1; SCN2A2
• UniProt Entry Name: SCN2A_HUMAN

NCBI Description

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels function in the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. Allelic variants of this gene are associated with seizure disorders and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]