PKA Ibeta reg Blocking Peptide | PKA blocking peptide

PKA Ibeta reg (F138) Peptide

Cat. Num. AAA3002386

• Gene Names: PRKAR1B; PRKAR1
• Applications: Blocking
• Purity: Synthetic peptide PKA Ibeta reg (F138). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: PKA Ibeta reg; PKA Ibeta reg (F138) Peptide; PKARI beta; PRKAR 1; PRKAR 1B; PRKAR1; PRKAR1B; PKA blocking peptide

• Specificity: This peptide can be used with studies using MBS3002385 PKA Ibeta reg (F138) pAb.
• Purity/Purification: Synthetic peptide PKA Ibeta reg (F138). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 381

• Applicable Applications for PKA blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for PKA blocking peptide

The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated Calpha, Cbeta and Cgamma, that each represent specific gene products. Calpha and Cbeta are closely related (93% amino acid sequence similarity), whereas Cgamma displays 83% and 79% similarity to Calpha and Cbeta, respectively.

NCBI and Uniprot Product Information

• NCBI GI #: 258613969
• NCBI GeneID: 5575
• NCBI Accession #: NP_001158230.1
• NCBI GenBank Nucleotide #: NP_001158230.1
• UniProt Accession #: P31321
• NCBI Official Full Name: cAMP-dependent protein kinase type I-beta regulatory subunit
• NCBI Official Synonym Full Names: protein kinase cAMP-dependent type I regulatory subunit beta
• NCBI Official Symbol: PRKAR1B
• NCBI Official Synonym Symbols: PRKAR1
• NCBI Protein Information: cAMP-dependent protein kinase type I-beta regulatory subunit
• UniProt Protein Name: cAMP-dependent protein kinase type I-beta regulatory subunit
• Protein Family: Protein lysine acetyltransferase
• UniProt Gene Name: PRKAR1B
• UniProt Entry Name: KAP1_HUMAN

NCBI Description

The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]

Uniprot Description

PKAR1B: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKX; regulates this cAMP-dependent protein kinase. Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Belongs to the cAMP-dependent kinase regulatory chain family.

Protein type: Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: plasma membrane; cytosol; cAMP-dependent protein kinase complex

Molecular Function: cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; cAMP binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; signal transduction; protein amino acid phosphorylation; learning and/or memory; phospholipase C activation; energy reserve metabolic process; innate immune response; renal water homeostasis; blood coagulation; regulation of insulin secretion; transmembrane transport