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Immunohistochemistry (IHC) (Immunohistochemistry (IHC) analyzes of CGB (D131) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.)

Rabbit CGB Polyclonal Antibody | anti-CGB antibody

CGB (D131) Polyclonal Antibody

Gene Names
CGB3; CGB; CGB5; CGB7; CGB8; hCGB
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
CGB; Polyclonal Antibody; CGB (D131) Polyclonal Antibody; CG beta; CG-beta; CGB 3; CGB 5; CGB 7; CGB3; CGB5; CGB7; CGB8; Choriogonadotropin subunit beta; Chorionic gonadotrophin chain beta; Chorionic gonadotropin beta 3 subunit; Chorionic gonadotropin beta 3 subunit precursor; Chorionic gonadotropin beta chain; Chorionic gonadotropin beta polypeptide; Chorionic gonadotropin beta subunit; hCGB; Choriogonadotropin beta; hCG beta; anti-CGB antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
CGB (D131) polyclonal antibody detects endogenous levels of Choriogonadotropin subunit beta protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
165
Applicable Applications for anti-CGB antibody
Immunohistochemistry (IHC)
Application Notes
IHC: 1:50-1:200
Immunogen
Synthetic peptide, corresponding to amino acids 101-150 of Human CGB.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of CGB (D131) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.)

Immunohistochemistry (IHC) (Immunohistochemistry (IHC) analyzes of CGB (D131) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.)

Western Blot (WB)

(Western Blot (WB) analysis of CGB (D131) pAb at 1:500 dilutionLane1:MCF-7 whole cell lysate (40ug) Lane2:SP2/0 whole cell lysate (40ug) Lane3:H9C2 whole cell lysate (40ug) Lane4:Hela whole cell lysate (40ug))

Western Blot (WB) (Western Blot (WB) analysis of CGB (D131) pAb at 1:500 dilutionLane1:MCF-7 whole cell lysate (40ug) Lane2:SP2/0 whole cell lysate (40ug) Lane3:H9C2 whole cell lysate (40ug) Lane4:Hela whole cell lysate (40ug))
Related Product Information for anti-CGB antibody
Choriogonadotropin is a hormone produced by the placenta in the first trimester of pregnancy and exists as a heterodimer formed from a unique beta chain and an alpha chain common to all gonadotropins. The unique beta chain confers biological specificity to choriogonadotropin, luteinizing hormone and follicle stimulating hormone. The secreted alpha subunit maps to human chromosome 6 and the beta subunit of choriogonadotropin maps to human chromosome 19. Choriogonadotropin stimulates the ovaries to produce and maintain normal levels of the steroids essential for maintaining pregnancy, including estrogen and progesterone. Choriogonadotropin is a member of the cystine knot growth-factor superfamily, a group of proteins that contain a distinct arrangement of six cysteine residues and are expressed in placenta. The proper secretion and dimerization of choriogonadotropin depends on the conformation of the cystine knot, although biological activity is independent of this conformation.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 18kDa
NCBI Official Full Name
choriogonadotropin subunit beta 3
NCBI Official Synonym Full Names
chorionic gonadotropin subunit beta 3
NCBI Official Symbol
CGB3
NCBI Official Synonym Symbols
CGB; CGB5; CGB7; CGB8; hCGB
NCBI Protein Information
choriogonadotropin subunit beta 3
UniProt Protein Name
Choriogonadotropin subunit beta
Protein Family
UniProt Gene Name
CGB
UniProt Synonym Gene Names
CGB3; CG-beta
UniProt Entry Name
CGHB_HUMAN

NCBI Description

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CGB: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. Belongs to the glycoprotein hormones subunit beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: extracellular region

Molecular Function: hormone activity

Biological Process: cellular protein metabolic process; cell-cell signaling; apoptosis; peptide hormone processing; female gamete generation; signal transduction

Research Articles on CGB

Similar Products

Product Notes

The CGB cgb (Catalog #AAA3000574) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CGB (D131) Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CGB can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1:50-1:200. Researchers should empirically determine the suitability of the CGB cgb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CGB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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