HDAC9 / Histone Deacetylase 9 Recombinant Protein | HDAC9 recombinant protein

Human HDAC9 / Histone Deacetylase 9 Recombinant Protein

• Gene Names: HDAC9; HD7; HD9; HD7b; HDAC; HDRP; MITR; HDAC7; HDAC7B; HDAC9B; HDAC9FL
• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: HDAC9 / Histone Deacetylase 9; Human HDAC9 / Histone Deacetylase 9 Recombinant Protein; Histone deacetylase 9; HD9; Histone deacetylase 7B; HD7; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR; HDAC7; HDAC7B; HDRP; KIAA0744; MITR; HDAC9 recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
• Concentration: Reconstitution Dependent (varies by lot)
• Sequence Length: 588

• Applicable Applications for HDAC9 recombinant protein: ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
• Species: Human
• Tag: His
• Subunit: Homodimer. Interacts with CTBP1. The phosphorylated form interacts with 14-3-3 (By similarity). Interacts with HDAC1 and HDAC3, and probably with HDAC4 and HDAC5. Interacts with MEF2, MAPK10, ETV6, NCOR1 and BCL6. Interacts with FOXP3 in the absence of T-cell stimulation.
• Entry Function: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
• Preparation and Storage: Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 323423044
• NCBI GeneID: 9734
• NCBI Accession #: NP_001191073.1
• NCBI GenBank Nucleotide #: NP_001191073.1
• UniProt Accession #: Q9UKV0
• NCBI Official Full Name: histone deacetylase 9 isoform 6
• NCBI Official Synonym Full Names: histone deacetylase 9
• NCBI Official Symbol: HDAC9
• NCBI Official Synonym Symbols: HD7; HD9; HD7b; HDAC; HDRP; MITR; HDAC7; HDAC7B; HDAC9B; HDAC9FL
• NCBI Protein Information: histone deacetylase 9
• UniProt Protein Name: Histone deacetylase 9
• UniProt Gene Name: HDAC9
• UniProt Synonym Gene Names: HDAC7; HDAC7B; HDRP; KIAA0744; MITR; HD9; HD7; HD7b
• UniProt Entry Name: HDAC9_HUMAN

NCBI Description

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

HDAC9: a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Protein type: Transcription, coactivator/corepressor; Deacetylase; EC 3.5.1.98

Chromosomal Location of Human Ortholog: 7p21.1

Cellular Component: nucleoplasm; histone methyltransferase complex; transcription factor complex; histone deacetylase complex; cytoplasm; nucleus

Molecular Function: protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); protein kinase C binding; NAD-dependent histone deacetylase activity (H3-K14 specific); histone deacetylase binding; metal ion binding; protein deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription corepressor activity; transcription factor binding

Biological Process: Notch signaling pathway; regulation of skeletal muscle fiber development; B cell activation; transcription, DNA-dependent; cellular response to insulin stimulus; regulation of striated muscle cell differentiation; B cell differentiation; heart development; histone deacetylation; negative regulation of transcription from RNA polymerase II promoter; inflammatory response; negative regulation of transcription, DNA-dependent