Mouse Transforming growth factor beta-3 ELISA Kit | Tgfb3 elisa kit
Mouse Transforming growth factor beta-3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the transforming growth factor (TGF) beta superfamily of cell regulatory proteins that control adhesion, proliferation, differentiation and transformation of many cell types. The encoded protein likely undergoes proteolytic cleavage similar to the human ortholog to generate an active peptide from the C-terminal region (TGF-beta 3), which is rendered inactive by its non-covalent association with the N-terminal peptide called the "Latency-associated peptide." Mice lacking the encoded protein die shortly after birth, and display abnormal pulmonary development and defective palatogenesis. [provided by RefSeq, Jul 2015]
Uniprot Description
TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family.
Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Ligand, receptor tyrosine kinase; Secreted; Secreted, signal peptide
Cellular Component: cell soma; cell surface; cytoplasm; extracellular matrix; extracellular region; extracellular space; nucleus; proteinaceous extracellular matrix; secretory granule; T-tubule
Molecular Function: cytokine activity; growth factor activity; identical protein binding; protein heterodimerization activity; punt binding; transforming growth factor beta binding; transforming growth factor beta receptor binding
Biological Process: activation of MAPK activity; alveolus development; cell development; cell growth; embryonic development; embryonic neurocranium morphogenesis; growth; in utero embryonic development; intercellular junction assembly and maintenance; mammary gland development; negative regulation of cell proliferation; negative regulation of DNA replication; negative regulation of neuron apoptosis; negative regulation of transforming growth factor beta receptor signaling pathway; organ morphogenesis; palate development; positive regulation of apoptosis; positive regulation of cell division; positive regulation of collagen biosynthetic process; positive regulation of DNA replication; positive regulation of filopodium formation; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of MAPKKK cascade; response to estrogen stimulus; response to hypoxia; response to progesterone stimulus; SMAD protein nuclear translocation; transforming growth factor beta receptor signaling pathway