Human TYRO protein tyrosine kinase-binding protein ELISA Kit | TYROBP elisa kit

Human TYRO protein tyrosine kinase-binding protein ELISA Kit

Cat. Num. AAA2886582

• Gene Names: TYROBP; DAP12; KARAP; PLOSL
• Reactivity: Human
• Synonyms: TYRO protein tyrosine kinase-binding protein; Human TYRO protein tyrosine kinase-binding protein ELISA Kit; DNAX-activation protein 12; Killer-activating receptor-associated protein; KAR-associated protein; TYROBP; DAP12; KARAP; TYROBP elisa kit

• Reactivity: Human
• Sequence Length: 102

• Assay Type: Sandwich
• Detection Range: 0.156-10 ng/mL
• Sensitivity: 0.056ng/ml
• Intra-Assay CV: <=6.6%
• Inter-Assay CV: <=9.2%
• Recovery: 101%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 291045272
• NCBI GeneID: 7305
• NCBI Accession #: NP_001166985.1
• NCBI GenBank Nucleotide #: NM_001173514.1
• UniProt Accession #: O43914; Q6FGA5; Q9UMT3; A8K2X0; F5H389
• Molecular Weight: 11,043 Da
• NCBI Official Full Name: TYRO protein tyrosine kinase-binding protein isoform 3
• NCBI Official Synonym Full Names: TYRO protein tyrosine kinase binding protein
• NCBI Official Symbol: TYROBP
• NCBI Official Synonym Symbols: DAP12; KARAP; PLOSL
• NCBI Protein Information: TYRO protein tyrosine kinase-binding protein
• UniProt Protein Name: TYRO protein tyrosine kinase-binding protein
• Protein Family: TYRO protein tyrosine kinase-binding protein
• UniProt Gene Name: TYROBP
• UniProt Synonym Gene Names: DAP12; KARAP; KAR-associated protein
• UniProt Entry Name: TYOBP_HUMAN

NCBI Description

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

Uniprot Description

TYROBP: Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. Defects in TYROBP are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. Belongs to the TYROBP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: cell surface; integral to plasma membrane; intracellular; plasma membrane

Molecular Function: identical protein binding; protein binding; receptor binding; receptor signaling protein activity

Biological Process: axon guidance; cellular defense response; innate immune response; integrin-mediated signaling pathway; macrophage activation during immune response; neutrophil activation during immune response; regulation of immune response; signal transduction

Disease: Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy