Rat D (3) dopamine receptor (DRD3) ELISA Kit | DRD3 elisa kit
Rat D (3) dopamine receptor (DRD3) ELISA Kit
Reactivity
Rat
Synonyms
D (3) dopamine receptor (DRD3); Rat D (3) dopamine receptor (DRD3) ELISA Kit; D3DR; ETM1; FET1; MGC149204; MGC149205; essential tremor 1; DRD3 elisa kit
Reactivity
Rat
Specificity
This assay has high sensitivity and excellent specificity for detection of Rat DRD3. No significant cross-reactivity or interference between Rat DRD3 and analogues was observed.
Sequence Length
446
Assay Type
Quantitive Sandwich
Samples
Serum, Plasma, Other Biological Fluids
Detection Wavelength
450 nm
Intra-assay Precision (Precision within an assay)
Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Inter-assay Precision (Precision between assays)
Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.
CV (%)
= SD/meanX100
Intra-Assay
CV
Inter-Assay
CV
Preparation and Storage
Store at 2-8 degree C.
Related Product Information for DRD3 elisa kit
Description: This assay employs a two-site sandwich ELISA to quantitate DRD3 in samples. An antibody specific for DRD3 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any DRD3 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for DRD3 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of DRD3 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Overview: D3 dopamine receptor inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is expressed in phylogenetically older regions of the brain, suggesting that this receptor plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson's disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay. Numerous non-selective prescription drugs bind to the D3 receptor, notably including some of the newer dopamine agonists used for Parkinson's disease such as pramipexole and ropinirole, but these also bind to D2 and lack the strong receptor type and subtype selectivity that some of the following research compounds afford.
Overview: D3 dopamine receptor inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is expressed in phylogenetically older regions of the brain, suggesting that this receptor plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson's disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay. Numerous non-selective prescription drugs bind to the D3 receptor, notably including some of the newer dopamine agonists used for Parkinson's disease such as pramipexole and ropinirole, but these also bind to D2 and lack the strong receptor type and subtype selectivity that some of the following research compounds afford.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
47,633 Da
NCBI Official Full Name
D(3) dopamine receptor
NCBI Official Synonym Full Names
dopamine receptor D3
NCBI Official Symbol
Drd3
NCBI Protein Information
D(3) dopamine receptor
UniProt Protein Name
D(3) dopamine receptor
Protein Family
UniProt Gene Name
Drd3
NCBI Description
may be involved in facilitating the effects of antipsychotic drugs and drug treatments for Parkinson's disease [RGD, Feb 2006]
Uniprot Description
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation ().
Research Articles on DRD3
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Product Notes
The Rat DRD3 drd3 (Catalog #AAA2800152) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2800152 ELISA Kit recognizes Rat DRD3. It is sometimes possible for the material contained within the vial of "D (3) dopamine receptor (DRD3), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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