Immunohistochemistry (IHC)
(Anti-DRD3 / Dopamine Receptor D3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Rabbit DRD3 / Dopamine Receptor D3 Polyclonal Antibody | anti-DRD3 antibody
Rabbit Polyclonal to Human DRD3 / Dopamine Receptor D3
Predicted Reactivity: Gibbon, Mouse, Bat, Bovine, Dog, Hamster, Horse, Rabbit (at least 90% immunogen sequence identity)
Predicted Reactivity: Gibbon, Mouse, Bat, Bovine, Dog, Hamster, Horse, Rabbit (at least 90% immunogen sequence identity)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
Immunohistochemistry (IHC)
(Anti-DRD3 / Dopamine Receptor D3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-DRD3 / Dopamine Receptor D3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Uniprot Description
DRD3: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. Genetic variation in DRD3 is associated with essential tremor hereditary type 1 (ETM1). ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3q13.3
Cellular Component: cell projection; integral to plasma membrane; endocytic vesicle; apical part of cell; plasma membrane
Molecular Function: dopamine D2 receptor-like receptor activity; protein domain specific binding; protein binding; dopamine binding; drug binding; D1 dopamine receptor binding
Biological Process: synaptic transmission, dopaminergic; regulation of lipid metabolic process; prepulse inhibition; musculoskeletal movement, spinal reflex action; response to morphine; locomotory behavior; negative regulation of transcription from RNA polymerase II promoter; regulation of dopamine secretion; dopamine metabolic process; dopamine receptor, adenylate cyclase inhibiting pathway; learning and/or memory; behavioral response to cocaine; positive regulation of cell proliferation; renin-angiotensin regulation of blood volume; visual learning; circadian regulation of gene expression; negative regulation of blood pressure; negative regulation of sodium:hydrogen antiporter activity; dopamine receptor, adenylate cyclase activating pathway; positive regulation of cytokinesis; response to drug; positive regulation of dopamine receptor signaling pathway; negative regulation of protein secretion; negative regulation of protein kinase B signaling cascade; positive regulation of mitosis; regulation of cAMP metabolic process; response to amphetamine; negative regulation of adenylate cyclase activity; regulation of dopamine uptake; regulation of multicellular organism growth; learning; social behavior; arachidonic acid secretion; response to cocaine; regulation of circadian sleep/wake cycle, sleep; negative regulation of oligodendrocyte differentiation; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; negative regulation of dopamine receptor signaling pathway; acid secretion; response to ethanol; G-protein coupled receptor internalization; positive regulation of transcription from RNA polymerase II promoter
Disease: Schizophrenia; Tremor, Hereditary Essential, 1
Research Articles on DRD3
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Product Notes
The DRD3 drd3 (Catalog #AAA240911) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human DRD3 / Dopamine Receptor D3 reacts with Chimpanzee, Gorilla, Human, Monkey Predicted Reactivity: Gibbon, Mouse, Bat, Bovine, Dog, Hamster, Horse, Rabbit (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's DRD3 / Dopamine Receptor D3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), ELISA (EIA). ELISA, IHC-P (20 ug/ml) Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.. Researchers should empirically determine the suitability of the DRD3 drd3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DRD3 / Dopamine Receptor D3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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