Canine Platelet Antibodies IgA ELISA Kit | PA-IgA elisa kit

Canine Platelet Antibodies IgA ELISA Kit

Gene Names

Prdm16; csp1; mel1; 5730557K01Rik

Reactivity

Canine

Synonyms

Platelet Antibodies IgA; Canine Platelet Antibodies IgA ELISA Kit; PA-IgA elisa kit

Ordering
Cat. Num. AAA25904 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Reactivity

Canine

Sequence Length

1178

Assay Type

Sandwich

Preparation and Storage

Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

NCBI GI #

597517970

NCBI GeneID

70673

NCBI Accession #

NP_001277958.1

NCBI GenBank Nucleotide #

NM_001291029.1

UniProt Accession #

A2A935; Q69ZD6; Q6PB79; Q7TPF4

Molecular Weight

140,858 Da

NCBI Official Full Name

PR domain zinc finger protein 16 isoform 4

NCBI Official Synonym Full Names

PR domain containing 16

NCBI Official Symbol

Prdm16

NCBI Official Synonym Symbols

csp1; mel1; 5730557K01Rik

NCBI Protein Information

PR domain zinc finger protein 16; line 27; MDS1/EVI1-like gene 1; transcription factor MEL1; PR domain-containing protein 16

UniProt Protein Name

PR domain zinc finger protein 16

UniProt Gene Name

Prdm16

UniProt Synonym Gene Names

Kiaa1675; Mel1; MDS1/EVI1-like gene 1

UniProt Entry Name

PRD16_MOUSE

Uniprot Description

PRDM16: binds DNA and functions as a transcriptional regulator. A repressor of TGF-beta signaling. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Interacts with HDAC1, SKI, SMAD2 and SMAD3; the interaction with SKI promotes the recruitment of SMAD3-HDAC1 complex on the promoter of TGF-beta target genes. A chromosomal aberration involving PRDM16 is found in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Reciprocal translocation t(1;3)(p36;q21). Isoform 4 is specifically expressed in adult T-cell leukemia. Four human isoforms are produced by alternative promoter usage and alternative splicing

Protein type: C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted

Cellular Component: transcriptional repressor complex; nucleus

Molecular Function: protein binding; transcription activator binding; DNA binding; nucleic acid binding; sequence-specific DNA binding; metal ion binding; transcription coactivator activity; SMAD binding

Biological Process: tongue development; transcription, DNA-dependent; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; palate development; negative regulation of granulocyte differentiation; regulation of cellular respiration; neurogenesis; regulation of transcription, DNA-dependent; white fat cell differentiation; brown fat cell differentiation; cell differentiation; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway

Research Articles on PA-IgA

1. These findings indicate that PRDM16 and beige adipocytes are required for the "browning" of white fat and the healthful effects of subcutaneous adipose tissue.

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Product Notes

The Canine PA-IgA prdm16 (Catalog #AAA025904) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA025904 ELISA Kit recognizes Canine PA-IgA. It is sometimes possible for the material contained within the vial of "Platelet Antibodies IgA, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Canine Platelet Antibodies IgA ELISA Kit | PA-IgA elisa kit