MKI67 Protein Recombinant Protein | MKI67 recombinant protein

Recombinant Human MKI67 Protein

Cat. Num. AAA2569300

• Gene Names: MKI67; KIA
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: MKI67 Protein; Recombinant Human MKI67 Protein; Proliferation marker protein Ki-67; Antigen identified by monoclonal antibody Ki-67; Antigen KI-67; Antigen Ki67; MKI67 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.5, 5% trehalose, 5% mannitol, 0.01% tween-80.
• Sequence: Met1-Pro120

• Species: Human
• Tag: N-His
• Protein Construction: A DNA sequence encoding the Human MKI67 Protein (P46013)(1-120) was expressed with a polyhistidine tag at the N-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 40 months.; This product is provided as lyophilized powder which is shipped with ice packs.

Related Product Information for MKI67 recombinant protein

Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226)

Product Categories/Family for MKI67 recombinant protein

Cancer; Cell Biology; Neuroscience; Tags & Cell Markers

NCBI and Uniprot Product Information

• NCBI GI #: 225543215
• NCBI GeneID: 4288
• NCBI Accession #: NP_001139438.1
• NCBI GenBank Nucleotide #: NM_001145966.1
• UniProt Accession #: P46013; Q5VWH2
• Molecular Weight: 358,694 Da
• NCBI Official Full Name: antigen KI-67 isoform 2
• NCBI Official Synonym Full Names: antigen identified by monoclonal antibody Ki-67
• NCBI Official Symbol: MKI67
• NCBI Official Synonym Symbols: KIA
• NCBI Protein Information: antigen KI-67; proliferation-related Ki-67 antigen
• UniProt Protein Name: Antigen KI-67
• Protein Family: Proliferation marker protein
• UniProt Gene Name: MKI67
• UniProt Entry Name: KI67_HUMAN

NCBI Description

This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]

Uniprot Description

KI-67: a protein that may be a marker of proliferating cells, involved in chromatin compaction. Its expression is altered in many tumor types including osteosarcomas, histiocytomas, prostate, breast and esophageal cancers. Mutated in colon, cervical and lung cancers.

Protein type: Nucleolus; Cell cycle regulation

Chromosomal Location of Human Ortholog: 10q26.2

Cellular Component: membrane; cytoplasm; nucleolus; condensed chromosome; nucleus; chromosome, pericentric region

Molecular Function: protein C-terminus binding; protein binding; ATP binding

Biological Process: cell proliferation; meiosis