Western Blot (WB)
(Western blot analysis of extracts of various cell lines using ZC3HAV1 Polyclonal Antibody at dilution of 1:3000.)
Rabbit anti-Human, Mouse ZC3HAV1 Polyclonal Antibody | anti-ZC3HAV1 antibody
ZC3HAV1 Polyclonal Antibody
Western Blot (WB)
(Western blot analysis of extracts of various cell lines using ZC3HAV1 Polyclonal Antibody at dilution of 1:3000.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines using ZC3HAV1 Polyclonal Antibody at dilution of 1:3000.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided by RefSeq, Jul 2008]
Uniprot Description
ZAP: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to remove the poly(A) tail, and the 3'- 5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; RNA-binding
Chromosomal Location of Human Ortholog: 7q34
Cellular Component: Golgi apparatus; cytoplasm; nucleus
Molecular Function: protein binding; metal ion binding; NAD+ ADP-ribosyltransferase activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of viral genome replication; metabolic process; response to virus; positive regulation of interferon-beta production; innate immune response; defense response to virus; positive regulation of interferon-alpha production
Research Articles on ZC3HAV1
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Product Notes
The ZC3HAV1 zc3hav1 (Catalog #AAA2566844) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ZC3HAV1 Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ZC3HAV1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the ZC3HAV1 zc3hav1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZC3HAV1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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