Rabbit anti-Human, Mouse DHX36 Polyclonal Antibody | anti-DHX36 antibody

DHX36 Polyclonal Antibody

Cat. Num. AAA2562691

• Gene Names: DHX36; G4R1; RHAU; DDX36; MLEL1
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: DHX36; Polyclonal Antibody; DHX36 Polyclonal Antibody; DDX36; DEAH box protein 36; Dhx36; EC 3.6.1.-; KIAA1488; MLE like protein 1; MLE-like protein 1; MLEL1; Probable ATP dependent RNA helicase DHX36; Probable ATP-dependent RNA helicase DHX36; RHAU; RNA helicase associated with AU rich element ARE; RNA helicase associated with AU-rich element ARE; anti-DHX36 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.54mg/mL (varies by lot)
• Sequence Length: 1008

• Applicable Applications for anti-DHX36 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:20-1:100; ELISA: 1:5000-1:10000
• Immunogen: Fusion protein of human DHX36
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using DHX36 Polyclonal Antibody at dilution of 1:30(×200))

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using DHX36 Polyclonal Antibody at dilution of 1:30(×200))

Related Product Information for anti-DHX36 antibody

This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms.

Product Categories/Family for anti-DHX36 antibody

Cancer; Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 313104099
• NCBI GeneID: 170506
• UniProt Accession #: Q9H2U1
• NCBI Official Full Name: ATP-dependent DNA/RNA helicase DHX36
• NCBI Official Synonym Full Names: DEAH-box helicase 36
• NCBI Official Symbol: DHX36
• NCBI Official Synonym Symbols: G4R1; RHAU; DDX36; MLEL1
• NCBI Protein Information: ATP-dependent DNA/RNA helicase DHX36
• UniProt Protein Name: ATP-dependent RNA helicase DHX36
• Protein Family: ATP-dependent RNA helicase
• UniProt Gene Name: DHX36
• UniProt Synonym Gene Names: DDX36; KIAA1488; MLEL1; RHAU; G4R1
• UniProt Entry Name: DHX36_HUMAN

NCBI Description

This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

DHX36: Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. Belongs to the DEAD box helicase family. DEAH subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.13; EC 3.6.4.12; Helicase; RNA-binding

Chromosomal Location of Human Ortholog: 3q25.2

Cellular Component: chromosome, telomeric region; cytoplasm; cytosol; nucleus

Molecular Function: G-quadruplex DNA binding; DNA-dependent ATPase activity; protein binding; histone deacetylase binding; double-stranded RNA binding; ATP-dependent RNA helicase activity; ATP binding

Biological Process: RNA processing; ossification; response to exogenous dsRNA; transcription, DNA-dependent; response to virus; RNA secondary structure unwinding; positive regulation of telomere maintenance; positive regulation of interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter