Rabbit anti-Human, Mouse IPO11 Polyclonal Antibody | anti-IPO11 antibody

IPO11 Polyclonal Antibody

Cat. Num. AAA2555446

• Gene Names: IPO11; RanBP11
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: IPO11; Polyclonal Antibody; IPO11 Polyclonal Antibody; Imp11; Importin 11; Importin-11; Ran binding protein 11; Ran-binding protein 11; RanBP11; SLRN; Synleurin; anti-IPO11 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1,015

• Applicable Applications for anti-IPO11 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant protein of human IPO11
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using IPO11 antibody.)

Product Categories/Family for anti-IPO11 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 198041777
• NCBI GeneID: 51194
• NCBI Accession #: NP_001128251.1
• NCBI GenBank Nucleotide #: NM_001134779.1
• UniProt Accession #: Q9UI26; Q8N5R2; Q9NSJ6; Q9NVB1; A6NGJ5; B4DZ73; D3DW98
• Molecular Weight: Calculated: 112kDa; 117kDa; Observed: 117kDa
• NCBI Official Full Name: importin-11 isoform 1
• NCBI Official Synonym Full Names: importin 11
• NCBI Official Symbol: IPO11
• NCBI Official Synonym Symbols: RanBP11
• NCBI Protein Information: importin-11
• UniProt Protein Name: Importin-11
• Protein Family: Importin
• UniProt Gene Name: IPO11
• UniProt Synonym Gene Names: RANBP11; Imp11; RanBP11

NCBI Description

Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]

Uniprot Description

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (). Mediates the nuclear import of UBE2E3, and of RPL12 ().