C-C Motif Chemokine 5 Recombinant Protein | Ccl5 recombinant protein

Recombinant Rat C-C Motif Chemokine 5 Protein

Cat. Num. AAA2553661

• Gene Names: Ccl5; Scya5; Rantes
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: C-C Motif Chemokine 5; Recombinant Rat C-C Motif Chemokine 5 Protein; SIS-delta; Small-inducible cytokine A5; T-cell-specific protein RANTES; Ccl5; Scya5; Ccl5 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 500mM NaCl, 2mM EDTA, pH 7.4.
• Sequence Positions: Ser25-Ser92
• Sequence Length: 92

• Species: Rat
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fusion Tag: N-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for Ccl5 recombinant protein

C-C motif chemokine 5(CCL5) is a beta-chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes. CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. Inflammatory responses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28. Oligomerization of CCL5 on glycosaminoglycans is required for CCR1mediated leukocyte adhesion and activation as well as CCL5's interaction with the chemokine CXCL4/PF4.The deposition of CCL5 on activated vascular endothelial cells is crucial for monocyte adhesion to damaged vasculature, but CCL5 oligomerization is not required for the extravasation of adherent leukocytes.CCL5 is upregulated in breast cancer and promotes tumor progression through the attraction of proinflammatory macrophages in addition to its actions on tumor cells, stromal cells, and the vasculature.

NCBI and Uniprot Product Information

• NCBI GI #: 1711393
• NCBI GeneID: 81780
• UniProt Accession #: P50231
• Molecular Weight: Molecular Mass: 10 kDa; Actual Protein Molecular Mass: 13 kDa
• NCBI Official Full Name: C-C motif chemokine 5
• NCBI Official Synonym Full Names: C-C motif chemokine ligand 5
• NCBI Official Symbol: Ccl5
• NCBI Official Synonym Symbols: Scya5; Rantes
• NCBI Protein Information: C-C motif chemokine 5
• UniProt Protein Name: C-C motif chemokine 5
• Protein Family: C-C motif chemokine
• UniProt Gene Name: Ccl5
• UniProt Synonym Gene Names: Scya5

NCBI Description

may play a role in cellular response to viral infection in testicular somatic cells [RGD, Feb 2006]

Uniprot Description

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.