B7-H3/CD276 recombinant protein

Recombinant Mouse B7-H3/CD276 Protein (C-6His)

Cat. Num. AAA2553445

• Gene Names: Cd276; B7h3; B7RP-2; AU016588; 6030411F23Rik
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: B7-H3/CD276; Recombinant Mouse B7-H3/CD276 Protein (C-6His); CD276 antigen; CD276; B7 homolog 3; B7-H3; B7-H3/CD276 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Positions: Val29-Phe244
• Sequence Length: 316

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for B7-H3/CD276 recombinant protein

CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20-27% amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration.

NCBI and Uniprot Product Information

• NCBI GI #: 19527206
• NCBI GeneID: 102657
• NCBI Accession #: NP_598744.1
• NCBI GenBank Nucleotide #: NM_133983.4
• UniProt Accession #: Q8VE98
• Molecular Weight: Molecular Mass: 24.3 kDa; Actual Protein Molecular Mass: 67kDa
• NCBI Official Full Name: CD276 antigen
• NCBI Official Synonym Full Names: CD276 antigen
• NCBI Official Symbol: Cd276
• NCBI Official Synonym Symbols: B7h3; B7RP-2; AU016588; 6030411F23Rik
• NCBI Protein Information: CD276 antigen
• UniProt Protein Name: CD276 antigen
• UniProt Gene Name: Cd276
• UniProt Synonym Gene Names: B7h3; B7-H3

Uniprot Description

Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. Plays a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells.