Junctional Adhesion Molecule B/JAM-B/CD322 Recombinant Protein | JAM-B/CD322 recombinant protein

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 Protein (C-Fc)

Gene Names

JAM2; JAMB; CD322; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43

Purity

>95% as determined by reducing SDS-PAGE.

Synonyms

Junctional Adhesion Molecule B/JAM-B/CD322; Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 Protein (C-Fc); Junctional Adhesion Molecule B; JAM-B; Junctional Adhesion Molecule 2; JAM-2; Vascular Endothelial Junction-Associated Molecule; VE-JAM; CD322; JAM2; C21orf43; VEJAM; JAM-B/CD322 recombinant protein

Ordering
Cat. Num. AAA2552873 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Host

Human Cells

Purity/Purification

>95% as determined by reducing SDS-PAGE.

Form/Format

Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.

Sequence Positions

Phe29-Asn236

Sequence Length

262

Species

Human

Endotoxin

<1.0 EU per ug as determined by LAL test.

Fusion Tag

C-Fc

Preparation and Storage

Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for JAM-B/CD322 recombinant protein

Junctional Adhesion Molecule B (JAM-B) is a single-pass type I membrane protein that belongs to the juctional adhesion molecules family. JAM-B includes a signal sequence (aa 1-28), an extracellular region (aa 29-238) with one Ig-like C2-type domain and one Ig-like V-type domain, a transmembrane segment (aa 239-259), and a cytoplasmic domain (aa 260 - 298). JAMB is localized to the tight junctions between endothelial cells or epithelial cells. JAM-B is prominently expressed in the heart, placenta, lung, foreskin and lymph node. It is also present on the endothelia of other vessels. JAM-B acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.

NCBI and Uniprot Product Information

NCBI GI #

393715111

NCBI GeneID

58494

NCBI Accession #

NP_001257336.1

NCBI GenBank Nucleotide #

NM_001270407.1

UniProt Accession #

P57087; Q6UXG6; Q6YNC1; B2R6T9; B4DGT9

Molecular Weight

Molecular Mass: 50.3 kDa
Actual Protein Molecular Mass: 60-75 kDa

NCBI Official Full Name

junctional adhesion molecule B isoform 2

NCBI Official Synonym Full Names

junctional adhesion molecule 2

NCBI Official Symbol

JAM2

NCBI Official Synonym Symbols

JAMB; CD322; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43

NCBI Protein Information

junctional adhesion molecule B

UniProt Protein Name

Junctional adhesion molecule B

UniProt Gene Name

JAM2

UniProt Synonym Gene Names

C21orf43; VEJAM; JAM-B; JAM-2; VE-JAM

NCBI Description

This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]

Uniprot Description

May play a role in the processes of lymphocyte homing to secondary lymphoid organs.

Research Articles on JAM-B/CD322

1. this review briefly focuses on what is currently known about the structure, function, and mechanism of JAM-B, with particular emphasis on cancer. [review]

Similar Products

JAM2 Recombinant Protein

Host: E Coli or Yeast or Baculovirus or Mammalian Cell

Reactivity: n/a

Apps: n/a

Product Notes

The JAM-B/CD322 jam2 (Catalog #AAA2552873) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Phe29-Asn236. It is sometimes possible for the material contained within the vial of "Junctional Adhesion Molecule B/JAM-B/CD322, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

Loading...