Ephrin-A3/EFNA3 Recombinant Protein | EFNA3 recombinant protein

Recombinant Human Ephrin-A3/EFNA3 Protein (C-6His)

Cat. Num. AAA2552627

• Gene Names: EFNA3; EFL2; EPLG3; LERK3; Ehk1-L
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Ephrin-A3/EFNA3; Recombinant Human Ephrin-A3/EFNA3 Protein (C-6His); Ephrin-A3; EFL-2; EHK1 Ligand; EHK1-L; EPH-Related Receptor Tyrosine Kinase Ligand 3; LERK-3; EFNA3; EFL2; EPLG3; LERK3; EFNA3 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
• Sequence Positions: Gln23-Ser211
• Sequence Length: 238

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for EFNA3 recombinant protein

Ephrins-A3 belongs the Ephrins ligand family which involved in a variety of biological processes, especially in the nervous system and in erythropoiesis. It is shown that Ephrin-A3 is expressed in brain, skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine, and peripheral blood leukocytes. Ephrin-A3 has a GPI anchor following the extracellular sequence and a signal sequence of 22 amino acids. Ephrin-A3 can bind EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8 and EphB1. Futhermore, it is associated with tumor growth and metastasis.

NCBI and Uniprot Product Information

• NCBI GI #: 4826708
• NCBI GeneID: 1944
• NCBI Accession #: NP_004943.1
• NCBI GenBank Nucleotide #: NM_004952.4
• UniProt Accession #: P52797; Q0VGC9; Q5SR70; B7ZAD3; D3DV85
• Molecular Weight: Molecular Mass: 22.3 kDa; Actual Protein Molecular Mass: 36 kDa
• NCBI Official Full Name: ephrin-A3
• NCBI Official Synonym Full Names: ephrin A3
• NCBI Official Symbol: EFNA3
• NCBI Official Synonym Symbols: EFL2; EPLG3; LERK3; Ehk1-L
• NCBI Protein Information: ephrin-A3
• UniProt Protein Name: Ephrin-A3
• Protein Family: Ephrin
• UniProt Gene Name: EFNA3
• UniProt Synonym Gene Names: EFL2; EPLG3; LERK3; EHK1-L; LERK-3

NCBI Description

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008]

Uniprot Description

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling ().