EDIL3/Del-1 recombinant protein

Recombinant Human EDIL3/Del-1 Protein (C-6His)

Cat. Num. AAA2552610

• Gene Names: EDIL3; DEL1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: EDIL3/Del-1; Recombinant Human EDIL3/Del-1 Protein (C-6His); EGF-Like Repeats and Discoidin I-Like Domains 3; EDIL3; EDIL3/Del-1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Positions: Val17-Glu480
• Sequence Length: 470

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for EDIL3/Del-1 recombinant protein

EGF-Like Repeat and Discoidin I-Like Domain-Containing Protein 3 (EDIL3) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. EDIL3 becomes quiescent at the time of birth, and is no longer expressed in normal adult tissues. EDIL3 has been found to be re-expressed in a number of human tumors as well as in ischemic muscles and ischemic brain tissue, which may play an important role in adult angiogenesis. EDIL3 promotes adherence and migration of endothelial cells, and acts as an endothelial cell survival agent through upregulation of Bcl-2 expression. EDIL3 has also been shown to be an endogenous inhibitor of inflammatory cell recruitment by interfering with the integrin LFA-1-dependent leukocyte-endothelial adhesion. Human EDIL3 is synthesized as a precursor with a 16 amino acid signal sequence and a 464 amino acid mature chain.

NCBI and Uniprot Product Information

• NCBI GI #: 522023554
• NCBI GeneID: 10085
• NCBI Accession #: NP_001265571.1
• NCBI GenBank Nucleotide #: NM_001278642.1
• UniProt Accession #: Q8N610; O43855; Q5D094; B2R763; O43854
• Molecular Weight: Molecular Mass: 53.1 kDa; Actual Protein Molecular Mass: 65 kDa
• NCBI Official Full Name: EGF-like repeat and discoidin I-like domain-containing protein 3 isoform 2
• NCBI Official Synonym Full Names: EGF like repeats and discoidin domains 3
• NCBI Official Symbol: EDIL3
• NCBI Official Synonym Symbols: DEL1
• NCBI Protein Information: EGF-like repeat and discoidin I-like domain-containing protein 3
• UniProt Protein Name: EGF-like repeat and discoidin I-like domain-containing protein 3
• UniProt Gene Name: EDIL3
• UniProt Synonym Gene Names: DEL1

NCBI Description

The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior. [provided by RefSeq, Jul 2008]

Uniprot Description

Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.