B3GNT1 recombinant protein

Recombinant Human B3GNT1 Protein (C-6His)

Cat. Num. AAA2552383

• Gene Names: B4GAT1; iGAT; iGNT; B3GNT1; B3GNT6; B3GN-T1; MDDGA13; BETA3GNTI
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: B3GNT1; Recombinant Human B3GNT1 Protein (C-6His); N-Acetyllactosaminide Beta-1; 3-N-Acetylglucosaminyltransferase; I-Beta-1; iGnT; Poly-N-Acetyllactosamine Extension Enzyme; UDP-GlcNAc:BetaGal Beta-1; 3-N-Acetylglucosaminyltransferase 1; B3GNT6; B3GNT1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Positions: Asp43-Cys415
• Sequence Length: 415

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for B3GNT1 recombinant protein

N-Acetyllactosaminide beta-1, 3-N-Acetylglucosaminyltransferase (B3GNT1) is a member of the beta-1, 3-N-Acetylglucosaminyltransferase family. B3GNT1 is a single-pass type II membrane protein and widely expressed in many tissues. B3GNT1 can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans. B3GNT1 is essential for the synthesis of poly-N-acetyllactosamine, a determinant for the blood group i antigen. It can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans.

NCBI and Uniprot Product Information

• NCBI GI #: 5802984
• NCBI GeneID: 11041
• NCBI Accession #: NP_006867.1
• NCBI GenBank Nucleotide #: NM_006876.2
• UniProt Accession #: O43505; Q4TTN0
• Molecular Weight: Molecular Mass: 43.4 kDa; Actual Protein Molecular Mass: 50 kDa
• NCBI Official Full Name: beta-1,4-glucuronyltransferase 1
• NCBI Official Synonym Full Names: beta-1,4-glucuronyltransferase 1
• NCBI Official Symbol: B4GAT1
• NCBI Official Synonym Symbols: iGAT; iGNT; B3GNT1; B3GNT6; B3GN-T1; MDDGA13; BETA3GNTI
• NCBI Protein Information: beta-1,4-glucuronyltransferase 1
• UniProt Protein Name: Beta-1,4-glucuronyltransferase 1
• UniProt Gene Name: B4GAT1
• UniProt Synonym Gene Names: B3GNT1ImportedManual assertion inferred from database entriesiHGNC:15685; B3GNT6; iGnT

NCBI Description

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It is essential for the synthesis of poly-N-acetyllactosamine, a determinant for the blood group i antigen. [provided by RefSeq, Jul 2008]

Uniprot Description

Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) ().