CD40 / TNFRSF5 recombinant protein
Recombinant Rat CD40 / TNFRSF5 Protein (His tag)
Description: A DNA sequence encoding the rat CD40 (Met1-Arg193) was expressed, fused with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
Uniprot Description
CD40: a member of the TNF-receptor superfamily. This receptor for CD40L mediates a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3). HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation. Two alternatively spliced isoforms have been reported. Isoform I is a type I membrane protein; isoform II is secreted.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 2 H3|2 85.38 cM
Cellular Component: cell soma; cell surface; cytoplasm; external side of plasma membrane; extracellular space; intracellular membrane-bound organelle; plasma membrane
Molecular Function: antigen binding; enzyme binding; protein binding; protein domain specific binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding
Biological Process: activation of NF-kappaB transcription factor; B cell activation; cellular calcium ion homeostasis; defense response to protozoan; defense response to virus; immune response-regulating cell surface receptor signaling pathway; inflammatory response; positive regulation of B cell proliferation; positive regulation of GTPase activity; positive regulation of interleukin-12 production; positive regulation of isotype switching to IgG isotypes; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat1 protein; protein kinase B signaling cascade; regulation of apoptosis; regulation of immune response; regulation of immunoglobulin secretion; response to lipopolysaccharide
Research Articles on CD40 / TNFRSF5
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Product Notes
The CD40 / TNFRSF5 cd40 (Catalog #AAA2547451) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant rat CD40 comprises 185 amino acids and predicts a molecular mass of 20.6 kDa. The apparent molecular mass of the recombinant protein is approximately 28 kDa in SDS-PAGE under reducing conditions due to glycosylation. Researchers should empirically determine the suitability of the CD40 / TNFRSF5 cd40 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD40 / TNFRSF5, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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