SDS-PAGE
IL1R2 / IL1RB / CD121b recombinant protein
Recombinant Rat IL1R2 / IL1RB / CD121b Protein (His tag)
Purity
> 97 % as determined by SDS-PAGE
Synonyms
IL1R2 / IL1RB / CD121b; Recombinant Rat IL1R2 / IL1RB / CD121b Protein (His tag); IL1R2; IL1R2 / IL1RB / CD121b recombinant protein
Host
Human Cells
Purity/Purification
> 97 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.5
Sequence Length
416
Application Notes
The recombinant rat IL1R2 comprises 353 amino acids and predicts a molecular mass of 39.7 kDa. The apparent molecular mass of the rat IL1R2 is approximately 55-60 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Predicted N Terminal
Phe 14
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for IL1R2 / IL1RB / CD121b recombinant protein
Background: Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct type s of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell type s including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.
Description: A DNA sequence encoding the rat IL1R2 (P43303) extracellular domain (Met 1-Glu 355) was expressed, fused with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the rat IL1R2 (P43303) extracellular domain (Met 1-Glu 355) was expressed, fused with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
46,353 Da
NCBI Official Full Name
interleukin-1 receptor type 2
NCBI Official Synonym Full Names
interleukin 1 receptor type 2
NCBI Official Symbol
Il1r2
NCBI Protein Information
interleukin-1 receptor type 2
UniProt Protein Name
Interleukin-1 receptor type 2
UniProt Gene Name
Il1r2
UniProt Synonym Gene Names
Il-1r2; Il1rb; IL-1R-2; IL-1RT-2; IL-1RT2; IL-1R-beta; mIL-1R2; mIL-1RII; sIL-1R2; sIL-1RII
NCBI Description
receptor for IL-1 alpha and IL-1 beta [RGD, Feb 2006]
Uniprot Description
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors ().
Research Articles on IL1R2 / IL1RB / CD121b
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Product Notes
The IL1R2 / IL1RB / CD121b il1r2 (Catalog #AAA2547431) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant rat IL1R2 comprises 353 amino acids and predicts a molecular mass of 39.7 kDa. The apparent molecular mass of the rat IL1R2 is approximately 55-60 kDa in SDS-PAGE under reducing conditions due to glycosylation. Researchers should empirically determine the suitability of the IL1R2 / IL1RB / CD121b il1r2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL1R2 / IL1RB / CD121b, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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