CTHRC1 recombinant protein
Rat CTHRC1 Protein (His Tag)
Purity
> 90 % as determined by SDS-PAGE.
Synonyms
CTHRC1; Rat CTHRC1 Protein (His Tag); CTHRC1 recombinant protein
Host
Human Cells
Purity/Purification
> 90 % as determined by SDS-PAGE.
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
230
Application Notes
The recombinant rat Cthrc1 consists 209 amino acids and predicts a molecular mass of 22.8 kDa.
Predicted N Terminal
Ser 33
Endotoxin
< 1.0 EU per mug protein as determined by the LAL method.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
Related Product Information for CTHRC1 recombinant protein
Background: Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to be responsible for trimerization of the CTHRC1 protein and this renders the molecule susceptible to cleavage by collagenase. CTHRC1 overexpression caused a dramatic reduction in collagen type I mRNA and protein levels. Currently available data indicate that Cthrc1 expression in vascular cells regulates transforming growth factor beta responsiveness, thereby impacting transforming growth factor beta target genes, including collagens. Additionally, CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis.
Description: A DNA sequence encoding the rat Cthrc1 (NP_001258229.1) (Met1-Lys230) was expressed with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the rat Cthrc1 (NP_001258229.1) (Met1-Lys230) was expressed with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
26,424 Da
NCBI Official Full Name
collagen triple helix repeat-containing protein 1 isoform 2
NCBI Official Synonym Full Names
collagen triple helix repeat containing 1
NCBI Official Symbol
Cthrc1
NCBI Protein Information
collagen triple helix repeat-containing protein 1
UniProt Protein Name
Collagen triple helix repeat-containing protein 1
Protein Family
UniProt Gene Name
Cthrc1
Uniprot Description
Its overexpression in smooth muscle cell lines increases their migratory ability and inhibits collagen type I expression. May act as a negative regulator of collagen matrix deposition.
Research Articles on CTHRC1
Similar Products
Product Notes
The CTHRC1 cthrc1 (Catalog #AAA2547269) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant rat Cthrc1 consists 209 amino acids and predicts a molecular mass of 22.8 kDa. Researchers should empirically determine the suitability of the CTHRC1 cthrc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CTHRC1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
