Cathepsin H / CTSH Recombinant Protein | CTSH recombinant protein

Recombinant Mouse Cathepsin H / CTSH Protein (His tag)

Cat. Num. AAA2546885

• Gene Names: Ctsh; AL022844
• Purity: > 90 % as determined by SDS-PAGE
• Synonyms: Cathepsin H / CTSH; Recombinant Mouse Cathepsin H / CTSH Protein (His tag); CTSH; CTSH recombinant protein

• Host: Human Cells
• Purity/Purification: > 90 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 333

• Application Notes: The recombinant mouse CTSH comprises 324 amino acids and has a predicted molecular mass of 36.6 kDa. The apparent molecular mass of the protein is approximately 42 kDa in SDS-PAGE under reducing conditions.
• Predicted N Terminal: Ala 21
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for CTSH recombinant protein

A DNA sequence encoding the mouse CTSH (AAA82966.1) (Ala21-Val333) was expressed with a C-terminal polyhistidine tag.

NCBI and Uniprot Product Information

• NCBI GI #: 454101
• NCBI GeneID: 13036
• Molecular Weight: 37,170 Da
• NCBI Official Full Name: cathepsin H prepropeptide
• NCBI Official Synonym Full Names: cathepsin H
• NCBI Official Symbol: Ctsh
• NCBI Official Synonym Symbols: AL022844
• NCBI Protein Information: pro-cathepsin H
• UniProt Protein Name: Pro-cathepsin H
• Protein Family: Pro-cathepsin
• UniProt Gene Name: Ctsh

NCBI Description

This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin H mini, heavy, and light chains. In rat and human, these three chains can associate to form the mature enzyme, which has both aminopeptidase and endopeptidase activities. Homozygous knockout mice for this gene exhibit impaired lung surfactant processing and reduced tumorigenesis in a pancreatic cancer model. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]

Uniprot Description

CTSH: Important for the overall degradation of proteins in lysosomes. Belongs to the peptidase C1 family.

Protein type: EC 3.4.22.16; Protease

Chromosomal Location of Human Ortholog: 9 E3.1|9 47.4 cM

Cellular Component: acrosome; axoneme; cytosol; extracellular space; lysosome; outer dense fiber

Molecular Function: aminopeptidase activity; apoptotic protease activator activity; caspase activator activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; endopeptidase activity; HLA-A specific activating MHC class I receptor activity; kininogen binding; peptidase activity; protein complex binding; protein self-association; serine-type endopeptidase activity

Biological Process: immune response-regulating signal transduction; membrane protein proteolysis; negative regulation of apoptosis; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cell proliferation; protein destabilization; proteolysis; proteolysis involved in cellular protein catabolic process; response to retinoic acid; surfactant homeostasis; T cell mediated cytotoxicity; zymogen activation