CLEC1A / CLEC-1 recombinant protein

Human CLEC1A / CLEC-1 Protein (Fc Tag)

Cat. Num. AAA2545558

• Gene Names: CLEC1A; CLEC1; CLEC-1
• Purity: > 95 % as determined by SDS-PAGE.
• Synonyms: CLEC1A / CLEC-1; Human CLEC1A / CLEC-1 Protein (Fc Tag); CLEC1; CLEC1A / CLEC-1 recombinant protein

• Host: Human Cells
• Purity/Purification: > 95 % as determined by SDS-PAGE.
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 280

• Application Notes: The recombinant human CLEC1A consists 464 amino acids and predicts a molecular mass of 51.9 kDa.
• Predicted N Terminal: Glu
• Endotoxin: < 1.0 EU per mug protein as determined by the LAL method.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for CLEC1A / CLEC-1 recombinant protein

Background: CLEC1A, also known as CLEC-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. CLEC1A contains 1 C-type lectin domain and is expressed preferentially in dendritic cells. It may play a role in regulating dendritic cell function. CLEC1A gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. Alternative splice variants have been described but their biological nature has not been determined. CLEC1A is found to be not only expressed in dendritic cells, but also in endothelial cells and in the latter aspect resembles the LOX-1 gene.

Description: A DNA sequence encoding the human CLEC1A (NP_057595.2) (Gln22-Asp280) was expressed with the Fc region of human IgG1 at the N-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 37577103
• NCBI GeneID: 51267
• NCBI Accession #: NP_057595.2
• NCBI GenBank Nucleotide #: NM_016511.3
• UniProt Accession #: Q8NC01; Q8IUW7; Q9NZH3
• Molecular Weight: 31,952 Da
• NCBI Official Full Name: C-type lectin domain family 1 member A isoform a
• NCBI Official Synonym Full Names: C-type lectin domain family 1 member A
• NCBI Official Symbol: CLEC1A
• NCBI Official Synonym Symbols: CLEC1; CLEC-1
• NCBI Protein Information: C-type lectin domain family 1 member A
• UniProt Protein Name: C-type lectin domain family 1 member A
• UniProt Gene Name: CLEC1A
• UniProt Synonym Gene Names: CLEC1; CLEC-1

NCBI Description

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

CLEC1A:

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.2

Cellular Component: integral to plasma membrane; intracellular

Molecular Function: transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; defense response