Rabbit anti-Mouse THSD1  Monoclonal Antibody | anti-THSD1  antibody

Rabbit anti Mouse THSD1  Monoclonal Antibody

Cat. Num. AAA2544567

• Gene Names: THSD1; TMTSP; UNQ3010
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: THSD1 ; Monoclonal Antibody; Rabbit anti Mouse THSD1 Monoclonal Antibody; anti-THSD1 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 799

• Applicable Applications for anti-THSD1 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse THSD1. The detection limit for Mouse THSD1 is approximately 0.0049 ng/well.
• Immunogen: Recombinant Mouse THSD1 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-THSD1  antibody

Thrombospondin type-1 domain-containing protein 1, also known as transmembrane molecule with thrombospondin module, THSD1 and TMTSP, is a single-pass type I membrane protein which contains one TSP type-1 domain. THSD1 is a multi-domain, multi-functional glycoprotein synthesized by many cells. Matricellular THSD1 modulates cell adhesion and proliferation. It is involved in angiogenesis, inflammation, wound healing and cancer. In vitro, nanomolar concentrations of Thrombospondin-1 are required to alter endothelial and vascular smooth muscle cell adhesion, proliferation, motility, and survival. As a major platelet protein, for a long time it was postulated to control hemostasis via platelet aggregate stabilization. THSD1 is a potent angiogenesis inhibitor, and down-regulation of THSD1 has been suggested to alter tumor growth by modulating angiogenesis in a variety of tumor types.

NCBI and Uniprot Product Information

• NCBI GI #: 40805852
• NCBI GeneID: 55901
• NCBI GenBank Nucleotide #: NM_199263.2
• Molecular Weight: 47,864 Da
• NCBI Official Full Name: thrombospondin type-1 domain-containing protein 1 isoform 2
• NCBI Official Synonym Full Names: thrombospondin type 1 domain containing 1
• NCBI Official Symbol: THSD1
• NCBI Official Synonym Symbols: TMTSP; UNQ3010
• NCBI Protein Information: thrombospondin type-1 domain-containing protein 1
• UniProt Protein Name: Thrombospondin type-1 domain-containing protein 1
• UniProt Gene Name: THSD1
• UniProt Synonym Gene Names: TMTSP
• UniProt Entry Name: THSD1_HUMAN

NCBI Description

The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jan 2009]

Uniprot Description

THSD1: contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jan 2009]

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q14.3

Cellular Component: cytoplasm