Rabbit anti-Mouse SCARB2  Monoclonal Antibody | anti-SCARB2  antibody

Rabbit anti Mouse SCARB2  Monoclonal Antibody

Cat. Num. AAA2544449

• Gene Names: SCARB2; AMRF; EPM4; LGP85; CD36L2; HLGP85; LIMP-2; LIMPII; SR-BII
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: SCARB2 ; Monoclonal Antibody; Rabbit anti Mouse SCARB2 Monoclonal Antibody; anti-SCARB2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 478

• Applicable Applications for anti-SCARB2 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse SCARB2. The detection limit for Mouse SCARB2 is approximately 0.0049 ng/well.
• Immunogen: Recombinant Mouse SCARB2 protein
• Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SCARB2/LIMP2 (rM SCARB2; Met 1-Thr 432; NP_031670.1).
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-SCARB2  antibody

Lysosomal Integral Membrane Protein II (LIMPII), also known as SCARB2, LPG85, and CD36L2, is a type I II multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. This protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. LIMPII is identified as a receptor for EV71 (human enterovirus species A, Enterovirus 71) and CVA16 (coxsackievirus A16) which are most frequently associated with hand, foot and mouth disease (HFMD). Expression of human LIMPII enables normally unsusceptible cell lines to support the viruses' propagation and develop cytopathic effects. In addition, LIMPII also has been shown to bind thrombospondin-1, may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation. Deficiency of the protein in mice impairs cell membrane transport processes and causes pelvic junction obstruction, deafness, and peripheral neuropathy.

NCBI and Uniprot Product Information

• NCBI GI #: 823669754
• NCBI GeneID: 950
• Molecular Weight: 37,767 Da
• NCBI Official Full Name: SCARB2, partial
• NCBI Official Synonym Full Names: scavenger receptor class B member 2
• NCBI Official Symbol: SCARB2
• NCBI Official Synonym Symbols: AMRF; EPM4; LGP85; CD36L2; HLGP85; LIMP-2; LIMPII; SR-BII
• NCBI Protein Information: lysosome membrane protein 2
• UniProt Protein Name: Lysosome membrane protein 2
• UniProt Gene Name: SCARB2
• UniProt Synonym Gene Names: CD36L2; LIMP2; LIMPII; LGP85; LIMP II
• UniProt Entry Name: SCRB2_HUMAN

NCBI Description

The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Uniprot Description

SCARB2: Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. Defects in SCARB2 are the cause of progressive myoclonic epilepsy type 4 with or without renal failure (EPM4). An autosomal recessive progressive myoclonic epilepsy associated with renal failure in some cases. Cognitive function is preserved. Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles. Cognitive function is preserved. Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease. Belongs to the CD36 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.

Chromosomal Location of Human Ortholog: 4q21.1

Cellular Component: focal adhesion; late endosome membrane; lysosomal lumen; lysosomal membrane; membrane

Molecular Function: enzyme binding; protein binding

Biological Process: protein targeting to lysosome

Disease: Epilepsy, Progressive Myoclonic 4, With Or Without Renal Failure