Rabbit anti-Mouse Fstl3/FLRG  Monoclonal Antibody | anti-Fstl3/FLRG  antibody

Rabbit anti Mouse Fstl3/FLRG  Monoclonal Antibody

Cat. Num. AAA2544439

• Gene Names: FSTL3; FLRG; FSRP
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: Fstl3/FLRG ; Monoclonal Antibody; Rabbit anti Mouse Fstl3/FLRG Monoclonal Antibody; anti-Fstl3/FLRG antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 263

• Applicable Applications for anti-Fstl3/FLRG antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse FLRG. The detection limit for Mouse FLRG is approximately 0.00975 ng/well.
• Immunogen: Recombinant Mouse FLRG protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-Fstl3/FLRG  antibody

Follistatin-like 3 (FLRG/Fstl3) is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. FLRG/Fstl3 is a recently described member of the FST family having an overall structure and activity profile similar to that of FST, including binding and neutralization of activin. FLRG/Fstl3 is expressed in a wide range of adult tissues, not detected in hematopoietic cells except in patients with a B cell chronic leukemia and a translocation. Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 of FLRG/Fstl3 or the nuclear form of FLRG/Fstl3 is probably involved in transcriptional regulation via interaction with MLLT10. Modulation of activin and other TGFbeta superfamily signaling is the primary mechanism of action for both follistatin (FS) and FS-like 3 (FSTL-3). FLRG/Fstl3 is likely to be a local regulator of activin action in gonadal development and gametogenesis and, further, that activin appears to have important actions in gonadal development and function that are critical for normal reproduction.

NCBI and Uniprot Product Information

• NCBI GI #: 5031701
• NCBI GeneID: 10272
• NCBI GenBank Nucleotide #: NM_005860.2
• Molecular Weight: 24,960 Da
• NCBI Official Full Name: follistatin-related protein 3
• NCBI Official Synonym Full Names: follistatin like 3
• NCBI Official Symbol: FSTL3
• NCBI Official Synonym Symbols: FLRG; FSRP
• NCBI Protein Information: follistatin-related protein 3
• UniProt Protein Name: Follistatin-related protein 3
• UniProt Gene Name: FSTL3
• UniProt Synonym Gene Names: FLRG
• UniProt Entry Name: FSTL3_HUMAN

NCBI Description

Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]

Uniprot Description

FSTL3: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Oncoprotein; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: extracellular region; extracellular space; nucleoplasm; nucleus

Molecular Function: activin binding; fibronectin binding; protein binding

Biological Process: hemopoietic progenitor cell differentiation; negative regulation of activin receptor signaling pathway; negative regulation of BMP signaling pathway; negative regulation of osteoclast differentiation; positive regulation of cell-cell adhesion; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter