Rabbit anti-Human F9  Monoclonal Antibody | anti-F9  antibody

Rabbit anti Human F9  Monoclonal Antibody

Cat. Num. AAA2544243

• Gene Names: F9; FIX; P19; PTC; HEMB; THPH8; F9 p22
• Reactivity: Human
• Applications: Western Blot, ELISA
• Synonyms: F9 ; Monoclonal Antibody; Rabbit anti Human F9 Monoclonal Antibody; anti-F9 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 461

• Applicable Applications for anti-F9 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 10-20 mug/mL; ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human F9. The detection limit for Human F9 is approximately 0.00245 ng/well.
• Immunogen: Recombinant Human Coagulation Factor IX/FIX/F9 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-F9  antibody

Coagulation factor IX, also known as Christmas factor, Plasma thromboplastin component and PTC, is a secreted protein which belongs to the peptidase S1 family. Coagulation factor IX/F9 contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one?peptidase S1 domain. Coagulation factor IX/F9 is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca2+ons, phospholipids, and factor VIIIa. Defects in Coagulation factor IX/F9 are the cause of thrombophilia due to factor IX defect which is a hemostatic disorder characterized by a tendency to thrombosis. Defects in Coagulation factor IX/F9 are also the cause of recessive X-linked hemophilia B (HEMB) which also known as Christmas disease.

NCBI and Uniprot Product Information

• NCBI GI #: 80479046
• NCBI GeneID: 2158
• Molecular Weight: 47,618 Da
• NCBI Official Full Name: F9 protein
• NCBI Official Synonym Full Names: coagulation factor IX
• NCBI Official Symbol: F9
• NCBI Official Synonym Symbols: FIX; P19; PTC; HEMB; THPH8; F9 p22
• NCBI Protein Information: coagulation factor IX
• UniProt Protein Name: Coagulation factor IX
• UniProt Gene Name: F9
• UniProt Synonym Gene Names: PTC
• UniProt Entry Name: FA9_HUMAN

NCBI Description

This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Sep 2015]

Uniprot Description

F9: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB); also known as Christmas disease. Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide. Defects in F9 are the cause of thrombophilia due to factor IX defect (THPH8). A hemostatic disorder characterized by a tendency to thrombosis. Belongs to the peptidase S1 family.

Protein type: EC 3.4.21.22; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xq27.1-q27.2

Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen; plasma membrane

Molecular Function: calcium ion binding; endopeptidase activity

Biological Process: blood coagulation; blood coagulation, extrinsic pathway; blood coagulation, intrinsic pathway; ER to Golgi vesicle-mediated transport; peptidyl-glutamic acid carboxylation; proteolysis; signal peptide processing; zymogen activation

Disease: Coumarin Resistance; Hemophilia B; Thrombophilia, X-linked, Due To Factor Ix Defect