Mouse anti-Human CD40/TNFRSF5 Monoclonal Antibody | anti-CD40/TNFRSF5 antibody

Mouse anti Human CD40/TNFRSF5 Monoclonal Antibody

Cat. Num. AAA2543464

• Gene Names: Cd40; IGM; p50; Bp50; GP39; IMD3; TRAP; HIGM1; T-BAM; Tnfrsf5; AI326936
• Reactivity: Human
• Applications: Immunocytochemistry, Immunofluorescence, Flow Cytometry, Functional Assay
• Synonyms: CD40/TNFRSF5; Monoclonal Antibody; Mouse anti Human CD40/TNFRSF5 Monoclonal Antibody; anti-CD40/TNFRSF5 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Sequence Length: 289

• Applicable Applications for anti-CD40/TNFRSF5 antibody: Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cyometry (FC/FACS)
• Application Notes: Flow Cytometry: 0.5-2 mug/Test; ICC/IF: 10-25 mug/mL
• Immunogen: Recombinant Human CD40/TNFRSF5 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 1553059
• NCBI GeneID: 21939
• Molecular Weight: 28,878 Da
• NCBI Official Full Name: CD40
• NCBI Official Synonym Full Names: CD40 antigen
• NCBI Official Symbol: Cd40
• NCBI Official Synonym Symbols: IGM; p50; Bp50; GP39; IMD3; TRAP; HIGM1; T-BAM; Tnfrsf5; AI326936
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 5
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 5
• UniProt Gene Name: Cd40
• UniProt Synonym Gene Names: Tnfrsf5
• UniProt Entry Name: TNR5_MOUSE

Uniprot Description

CD40: a member of the TNF-receptor superfamily. This receptor for CD40L mediates a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3). HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation. Two alternatively spliced isoforms have been reported. Isoform I is a type I membrane protein; isoform II is secreted.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: cell soma; cell surface; cytoplasm; external side of plasma membrane; extracellular space; intracellular membrane-bound organelle; plasma membrane

Molecular Function: antigen binding; enzyme binding; protein binding; protein domain specific binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding

Biological Process: activation of NF-kappaB transcription factor; B cell activation; cellular calcium ion homeostasis; defense response to protozoan; defense response to virus; immune response-regulating cell surface receptor signaling pathway; inflammatory response; positive regulation of B cell proliferation; positive regulation of GTPase activity; positive regulation of interleukin-12 production; positive regulation of isotype switching to IgG isotypes; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat1 protein; protein kinase B signaling cascade; regulation of apoptosis; regulation of immune response; regulation of immunoglobulin secretion; response to lipopolysaccharide