Rabbit anti-Human, Mouse NFKBID Polyclonal Antibody | anti-NFKBID antibody

NFKBID Polyclonal Antibody

Cat. Num. AAA2526915

• Gene Names: NFKBID; TA-NFKBH; IkappaBNS
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity purification
• Synonyms: NFKBID; Polyclonal Antibody; NFKBID Polyclonal Antibody; TA-NFKBH; IkappaBNS; anti-NFKBID antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
• Sequence Length: 150

• Applicable Applications for anti-NFKBID antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:200-1:1000; IHC 1:25-1:100
• Immunogen: Recombinant protein of human NFKBID
• Note: Centrifuge before opening to ensure complete recovery of vial contents.
• Preparation and Storage: Store at -20°C. Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of RAW264.7 cell using NFKBID Polyclonal Antibody at dilution of 1:650)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colon cancer using NFKBID Polyclonal Antibody at dilution of 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer using NFKBID Polyclonal Antibody at dilution of 1:40)

Related Product Information for anti-NFKBID antibody

May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes. I-kappa-BNS, the nuclear I-kappa-B-like protein encoded by Nfkbid, is required for the development of marginal zone and peritoneal B-1 B cells and additionally required for extrafollicular antibody responses to T-independent and -dependent immunogens. I-kappa-BNS has been identified as a member of the I-kappa-B family of NF-kappa-B inhibitors, which undergoes induction upon TCR signaling. I-kappa-BNS mediates both positive and negative gene regulation, depending on individual cell type and/or cytokine.

NCBI and Uniprot Product Information

• NCBI GI #: 13623339
• NCBI GeneID: 84807
• UniProt Accession #: BC006273; Q8NI39; Q9BRG9; Q8NI38
• Molecular Weight: 33kDa
• NCBI Official Full Name: NFKBID protein
• NCBI Official Synonym Full Names: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
• NCBI Official Symbol: NFKBID
• NCBI Official Synonym Symbols: TA-NFKBH; IkappaBNS
• NCBI Protein Information: NF-kappa-B inhibitor delta; I-kappa-B-delta; T-cell activation NFKB-like protein; ikB-delta; ikappaBdelta
• UniProt Protein Name: NF-kappa-B inhibitor delta
• Protein Family: NF-kappa-B inhibitor
• UniProt Gene Name: NFKBID
• UniProt Synonym Gene Names: IKBNS; IkB-delta; IkappaBdelta
• UniProt Entry Name: IKBD_HUMAN

Uniprot Description

NFKBID: May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR- induced negative selection of thymocytes. Belongs to the NF-kappa-B inhibitor family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: nucleus

Molecular Function: NF-kappaB binding

Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of T cell differentiation in the thymus; inflammatory response