Rabbit GNB1 Polyclonal Antibody | anti-GNB1 antibody

GNB1 Polyclonal Antibody

Cat. Num. AAA2518382

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: GNB1; Polyclonal Antibody; GNB1 Polyclonal Antibody; anti-GNB1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 0.8mg/mL (varies by lot)
• Sequence Length: 340

• Applicable Applications for anti-GNB1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:25-1:100
• Immunogen: Recombinant protein of human GNB1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of HepG2, A549, 293T and 231 cell using GNB1 Polyclonal Antibody at dilution of 1:400)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human brain using GNB1 Polyclonal Antibody at dilution of 1:20)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer using GNB1 Polyclonal Antibody at dilution of 1:20)

Related Product Information for anti-GNB1 antibody

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.

NCBI and Uniprot Product Information

• NCBI GI #: 543173169
• NCBI GeneID: 2782
• NCBI Accession #: NP_001269468.1
• NCBI GenBank Nucleotide #: NM_001282539.1
• Molecular Weight: 36,298 Da
• NCBI Official Full Name: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform 1
• NCBI Official Synonym Full Names: guanine nucleotide binding protein (G protein), beta polypeptide 1
• NCBI Official Symbol: GNB1
• NCBI Protein Information: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; G protein, beta-1 subunit; beta subunit, signal-transducing proteins GS/GI; transducin beta chain 1
• UniProt Protein Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
• UniProt Gene Name: GNB1
• UniProt Entry Name: GBB1_HUMAN

NCBI Description

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Description

G-beta 1: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the WD repeat G protein beta family.

Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric beta

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: photoreceptor inner segment; membrane; lysosomal membrane; dendrite; plasma membrane; heterotrimeric G-protein complex; intracellular; vesicle

Molecular Function: GTPase activity; GTPase binding; signal transducer activity; protein binding; spectrin binding; protein complex binding; type 1 angiotensin receptor binding

Biological Process: phototransduction, visible light; platelet activation; acetylcholine receptor signaling, muscarinic pathway; sensory perception of taste; signal transduction; rhodopsin mediated signaling; synaptic transmission; cell proliferation; elevation of cytosolic calcium ion concentration; regulation of rhodopsin mediated signaling; retina development in camera-type eye; Ras protein signal transduction; energy reserve metabolic process; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); blood coagulation; dopamine receptor, adenylate cyclase activating pathway