Rabbit GNB1 Polyclonal Antibody | anti-GNB1 antibody

GNB1 Rabbit pAb

Cat. Num. AAA4759930

• Gene Names: GNB1; MRD42
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: GNB1; Polyclonal Antibody; GNB1 Rabbit pAb; guanine nucleotide binding protein (G protein); beta polypeptide 1; anti-GNB1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: 0.2mg/ml (varies by lot)

• Applicable Applications for anti-GNB1 antibody: Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: WB: 1:500-1:2000; IHC-P: 1:25-1:100
• Immunogen: Fusion protein of human GNB1
• Conjugation: Unconjugated
• Modification: Unmodified
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Western Blot analysis of GNB1 in Hela, 293T and 231 cells in order using GNB1 Rabbit pAb at dilution 1/450)

Immunohistochemistry (IHC)

(Immunohistochemistry of GNB1 in paraffin-embedded Human liver cancer tissue using GNB1 Rabbit pAb at dilution 1/25. Predicted cell location: Cytoplasm and membrane)

Related Product Information for anti-GNB1 antibody

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.

NCBI and Uniprot Product Information

• NCBI GI #: 543173167
• NCBI GeneID: 2782
• NCBI Accession #: NP_001269467.1
• NCBI GenBank Nucleotide #: NM_001282538.1
• UniProt Accession #: P62873; P04697; P04901; Q1RMY8; B1AJZ7
• Molecular Weight: 36,298 Da
• NCBI Official Full Name: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform 2
• NCBI Official Synonym Full Names: G protein subunit beta 1
• NCBI Official Symbol: GNB1
• NCBI Official Synonym Symbols: MRD42
• NCBI Protein Information: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
• UniProt Protein Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
• UniProt Gene Name: GNB1

NCBI Description

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Description

G-beta 1: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the WD repeat G protein beta family.

Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric beta

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: cytosol; heterotrimeric G-protein complex; intracellular; lysosomal membrane; membrane; plasma membrane

Molecular Function: GTPase activity; GTPase binding; protein binding; protein complex binding

Biological Process: acetylcholine receptor signaling, muscarinic pathway; dopamine receptor, adenylate cyclase activating pathway; platelet activation; protein folding; Ras protein signal transduction; rhodopsin mediated signaling; signal transduction; Wnt receptor signaling pathway, calcium modulating pathway

Disease: Leukemia, Acute Lymphoblastic; Mental Retardation, Autosomal Dominant 42